Using Big Data in oncology to prospectively impact clinical patient care: A proof of concept study

Big Data is widely seen as a major opportunity for progress in the practice of personalized medicine, attracting the attention from medical societies and presidential teams alike as it offers a unique opportunity to enlarge the base of evidence, especially for older patients underrepresented in clin...

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Veröffentlicht in:Journal of geriatric oncology 2018-11, Vol.9 (6), p.665-672
Hauptverfasser: Dougoud-Chauvin, Vérène, Lee, Jae Jin, Santos, Edgardo, Williams, Vonetta L., Battisti, Nicolò M.L., Ghia, Kavita, Sehovic, Marina, Croft, Cortlin, Kim, Jongphil, Balducci, Lodovico, Kish, Julie A., Extermann, Martine
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Sprache:eng
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Zusammenfassung:Big Data is widely seen as a major opportunity for progress in the practice of personalized medicine, attracting the attention from medical societies and presidential teams alike as it offers a unique opportunity to enlarge the base of evidence, especially for older patients underrepresented in clinical trials. This study prospectively assessed the real-time availability of clinical cases in the Health & Research Informatics Total Cancer Care™ (TCC) database matching community patients with cancer, and the impact of such a consultation on treatment. Patients aged 70 and older seen at the Lynn Cancer Institute (LCI) with a documented malignancy were eligible. Geriatric screening information and the oncologist's pre-consultation treatment plan were sent to Moffitt. A search for similar patients was done in TCC and additional information retrieved from Electronic Medical Records. A report summarizing the data was sent and the utility of such a consultation was assessed per email after the treatment decision. Thirty one patients were included. The geriatric screening was positive in 87.1% (27) of them. The oncogeriatric consultation took on average 2.2 working days. It influenced treatment in 38.7% (12), and modified it in 19.4% (6). The consultation was perceived as “somewhat” to “very useful” in 83.9% (26). This study establishes a proof of concept of the feasibility of real time use of Big Data for clinical practice. The geriatric screening and the consultation report influenced treatment in 38.7% of cases and modified it in 19.4%, which compares very well with oncogeriatric literature. Additional steps are needed to render it financially and clinically viable.
ISSN:1879-4068
1879-4076
DOI:10.1016/j.jgo.2018.03.017