Impact of cytogenetics on outcomes in pediatric acute lymphoblastic leukemia

Impact of cytogenetics on outcomes in pediatric acute lymphoblastic leukemia

Abstract Context: In acute lymphoblastic leukemia (ALL), the most important prognostic factors are age, leukocyte count at presentation, immunophenotype, and cytogenetic abnormalities. The cytogenetic abnormalities are associated with distinct immunologic phenotypes of ALL and characteristic outcome...

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Veröffentlicht in:South Asian Journal of Cancer 2018-10, Vol.7 (4), p.263-266
Hauptverfasser: Chennamaneni, Rachana, Gundeti, Sadashivudu, Konatam, Meher Lakshmi, Bala, Stalin, Kumar, Ashok, Srinivas, Lakshmi
Format: Artikel
Sprache:eng
Schlagworte:
Acute lymphoblastic leukemia
cytogenetics
event-free survival
ORIGINAL ARTICLE: Hematolymphoid Malignancies
overall survival
pediatric
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Zusammenfassung:Abstract Context: In acute lymphoblastic leukemia (ALL), the most important prognostic factors are age, leukocyte count at presentation, immunophenotype, and cytogenetic abnormalities. The cytogenetic abnormalities are associated with distinct immunologic phenotypes of ALL and characteristic outcomes. Aims: The present study was primarily aimed at analyzing the impact of cytogenetics on postinduction responses and event-free survival (EFS) in pediatric patients with ALL. The secondary objective was to study the overall survival (OS). Subjects and Methods: A total of 240 patients with age
ISSN:2278-330X
2278-4306
DOI:10.4103/sajc.sajc_13_18