Differential Susceptibility to T Cell-Induced Colitis in Mice: Role of the Intestinal Microbiota

Abstract One of the best characterized mouse models of the inflammatory bowel diseases (IBD; Crohn's disease, ulcerative colitis) is the CD4+CD45RBhigh T cell transfer model of chronic colitis. Following our relocation to Texas Tech University Health Sciences Center (TTUHSC), we observed a dram...

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Veröffentlicht in:	Inflammatory bowel diseases 2018-01, Vol.24 (2), p.361-379
Hauptverfasser:	Reinoso Webb, Cynthia, den Bakker, Hendrik, Koboziev, Iurii, Jones-Hall, Yava, Rao Kottapalli, Kameswara, Ostanin, Dmitry, Furr, Kathryn L, Mu, Qinghui, Luo, Xin M, Grisham, Matthew B
Format:	Artikel
Sprache:	eng
Schlagworte:	Adoptive Transfer Animals Anti-Bacterial Agents - pharmacology Bacteria - classification Basic Science Research Colitis - immunology Colitis - microbiology Colon - drug effects Colon - pathology Disease Models, Animal Feces - microbiology Gastrointestinal Microbiome - drug effects Gastrointestinal Microbiome - immunology Male Mice Mice, Inbred C57BL Mice, Knockout RNA, Ribosomal, 16S - genetics T-Lymphocytes - immunology
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Zusammenfassung:	Abstract One of the best characterized mouse models of the inflammatory bowel diseases (IBD; Crohn's disease, ulcerative colitis) is the CD4+CD45RBhigh T cell transfer model of chronic colitis. Following our relocation to Texas Tech University Health Sciences Center (TTUHSC), we observed a dramatic reduction in the incidence of moderate-to-severe colitis from a 16-year historical average of 90% at Louisiana State University Health Sciences Center (LSUHSC) to
ISSN:	1078-0998 1536-4844
DOI:	10.1093/ibd/izx014