YAP/TAZ as therapeutic targets in cancer

Highlights • YAP/TAZ are activated in a broad number of solid tumors. • YAP/TAZ instrumental for tumor initiation, growth, metastasis and chemoresistance. • Several inputs control YAP/TAZ activity, offering new avenues for therapeutic exploration.

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Current opinion in pharmacology 2016-08, Vol.29, p.26-33
Hauptverfasser:	Zanconato, Francesca, Battilana, Giusy, Cordenonsi, Michelangelo, Piccolo, Stefano
Format:	Artikel
Sprache:	eng
Schlagworte:	Acyltransferases Adaptor Proteins, Signal Transducing - metabolism Animals Antineoplastic Agents - pharmacology Drug Design Humans Internal Medicine Medical Education Molecular Targeted Therapy Neoplasms - drug therapy Neoplasms - pathology Phosphoproteins - metabolism Transcription Factors - metabolism YAP-Signaling Proteins
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Highlights • YAP/TAZ are activated in a broad number of solid tumors. • YAP/TAZ instrumental for tumor initiation, growth, metastasis and chemoresistance. • Several inputs control YAP/TAZ activity, offering new avenues for therapeutic exploration.
ISSN:	1471-4892 1471-4973
DOI:	10.1016/j.coph.2016.05.002