Splenectomy modulates early immuno-inflammatory responses to trauma-hemorrhage and protects mice against secondary sepsis

In polytrauma patients, the impact of splenectomy is equivocal, ranging from negative to protective. We investigated the impact of splenectomy on immune responses in the 1 st -hit polytrauma alone and on survival in the post-traumatic sepsis (2 nd hit). Female BALB/c mice underwent polytrauma (1 st...

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Veröffentlicht in:	Scientific reports 2018-10, Vol.8 (1), p.14890-12, Article 14890
Hauptverfasser:	Drechsler, S., Zipperle, J., Rademann, P., Jafarmadar, M., Klotz, A., Bahrami, S., Osuchowski, M. F.
Format:	Artikel
Sprache:	eng
Schlagworte:	13 13/21 13/31 45 59 631/250/262 64/60 692/308/2778 692/699/249 692/699/578 Animal models Cecum Femur Fractures Hemorrhage Hemorrhagic shock Humanities and Social Sciences Immune response Inflammation Interleukin 6 Lymphocytes T Lymphocytosis Macrophages Major histocompatibility complex Monocyte chemoattractant protein 1 Monocytes multidisciplinary Neutrophilia Phagocytes Rodents Science Science (multidisciplinary) Sepsis Splenectomy Trauma
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