Splenectomy modulates early immuno-inflammatory responses to trauma-hemorrhage and protects mice against secondary sepsis

In polytrauma patients, the impact of splenectomy is equivocal, ranging from negative to protective. We investigated the impact of splenectomy on immune responses in the 1 st -hit polytrauma alone and on survival in the post-traumatic sepsis (2 nd hit). Female BALB/c mice underwent polytrauma (1 st...

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Veröffentlicht in:Scientific reports 2018-10, Vol.8 (1), p.14890-12, Article 14890
Hauptverfasser: Drechsler, S., Zipperle, J., Rademann, P., Jafarmadar, M., Klotz, A., Bahrami, S., Osuchowski, M. F.
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Sprache:eng
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Zusammenfassung:In polytrauma patients, the impact of splenectomy is equivocal, ranging from negative to protective. We investigated the impact of splenectomy on immune responses in the 1 st -hit polytrauma alone and on survival in the post-traumatic sepsis (2 nd hit). Female BALB/c mice underwent polytrauma (1 st hit) consisting of either a) TH: femur fracture, hemorrhagic shock or b) TSH: splenectomy, femur fracture, hemorrhagic shock. Additionally, the polytrauma hit was followed by cecal ligation and puncture (CLP) 48 h later and compared to CLP alone. Splenectomy improved the 28-day survival in secondary sepsis to 92% (from 62%), while TH lowered it to 46% (p 
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-018-33232-1