Phase 2 Trial of Ibudilast in Progressive Multiple Sclerosis

The antiinflammatory small molecule ibudilast was tested in a phase 2 trial in patients with progressive multiple sclerosis. The rate of brain atrophy over 96 weeks was lower with ibudilast than with placebo. Side effects with ibudilast included GI symptoms and depression.

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Veröffentlicht in:	The New England journal of medicine 2018-08, Vol.379 (9), p.846-855
Hauptverfasser:	Fox, Robert J, Coffey, Christopher S, Conwit, Robin, Cudkowicz, Merit E, Gleason, Trevis, Goodman, Andrew, Klawiter, Eric C, Matsuda, Kazuko, McGovern, Michelle, Naismith, Robert T, Ashokkumar, Akshata, Barnes, Janel, Ecklund, Dixie, Klingner, Elizabeth, Koepp, Maxine, Long, Jeffrey D, Natarajan, Sneha, Thornell, Brenda, Yankey, Jon, Bermel, Robert A, Debbins, Josef P, Huang, Xuemei, Jagodnik, Patricia, Lowe, Mark J, Nakamura, Kunio, Narayanan, Sridar, Sakaie, Ken E, Thoomukuntla, Bhaskar, Zhou, Xiaopeng, Krieger, Stephen, Alvarez, Enrique, Apperson, Michelle, Bashir, Khurram, Cohen, Bruce A, Coyle, Patricia K, Delgado, Silvia, Dewitt, L. Dana, Flores, Angela, Giesser, Barbara S, Goldman, Myla D, Jubelt, Burk, Lava, Neil, Lynch, Sharon G, Moses, Harold, Ontaneda, Daniel, Perumal, Jai S, Racke, Michael, Repovic, Pavle, Riley, Claire S, Severson, Christopher, Shinnar, Shlomo, Suski, Valerie, Weinstock-Guttman, Bianca, Yadav, Vijayshree, Zabeti, Aram
Format:	Artikel
Sprache:	eng
Schlagworte:	3',5'-Cyclic-nucleotide phosphodiesterase Adult Atrophy Atrophy - prevention & control Brain - diagnostic imaging Brain - pathology Cortex Depression - chemically induced Diffusion Tensor Imaging Disease Progression Double-Blind Method Drug dosages Female Gastrointestinal Diseases - chemically induced Headache Headache - chemically induced Humans Leukocyte migration Macrophage migration inhibitory factor Magnetic resonance imaging Male Mental depression Middle Aged Multiple sclerosis Multiple Sclerosis, Chronic Progressive - drug therapy Multiple Sclerosis, Chronic Progressive - pathology Nervous system Neuroimaging Neurological diseases Neurological disorders NMR Nuclear magnetic resonance Phosphodiesterase Inhibitors - adverse effects Phosphodiesterase Inhibitors - therapeutic use Pyramidal tracts Pyridines - adverse effects Pyridines - therapeutic use Retina TLR4 protein Toll-like receptors Vertigo
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Beschreibung
Zusammenfassung:	The antiinflammatory small molecule ibudilast was tested in a phase 2 trial in patients with progressive multiple sclerosis. The rate of brain atrophy over 96 weeks was lower with ibudilast than with placebo. Side effects with ibudilast included GI symptoms and depression.
ISSN:	0028-4793 1533-4406 1533-4406
DOI:	10.1056/NEJMoa1803583