Simvastatin Protects Cardiomyocytes Against Endotoxin-induced Apoptosis and Up-regulates Survivin/NF-κB/p65 Expression

Simvastatin Protects Cardiomyocytes Against Endotoxin-induced Apoptosis and Up-regulates Survivin/NF-κB/p65 Expression

This study is aimed to investigate whether simvastatin induces cardiomyocytes survival signaling in endotoxin (lipopolysaccharide, LSP)-induced myocardial injury, and if so, further to determine a role of survivin in simvastatin-anti-apoptotic effect. Wistar rats were pretreated with simvastatin (10...

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Veröffentlicht in:Scientific reports 2018-10, Vol.8 (1), p.14652-10, Article 14652
Hauptverfasser: Nežić, Lana, Škrbić, Ranko, Amidžić, Ljiljana, Gajanin, Radoslav, Kuča, Kamil, Jaćević, Vesna
Format: Artikel
Sprache:eng
Schlagworte:
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Apoptosis
Bcl-x protein
Cardiomyocytes
Caspase
Caspase-3
Endotoxins
Humanities and Social Sciences
Inflammation
Lethal dose
Lipopolysaccharides
multidisciplinary
Myofibrils
NF-κB protein
Rodents
Science
Science (multidisciplinary)
Sepsis
Simvastatin
Survivin
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Zusammenfassung:This study is aimed to investigate whether simvastatin induces cardiomyocytes survival signaling in endotoxin (lipopolysaccharide, LSP)-induced myocardial injury, and if so, further to determine a role of survivin in simvastatin-anti-apoptotic effect. Wistar rats were pretreated with simvastatin (10–40 mg/kg po ) before a single non-lethal dose of LPS. In myocardial tissue, LPS induced structural disorganization of myofibrils with significant inflammatory infiltrate (cardiac damage score, CDS = 3.87 ± 0.51, p  
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-018-32376-4