Novel photoactivatable substrates for Renilla luciferase imaging in vitro and in vivo

Novel photoactivatable substrates for Renilla luciferase imaging in vitro and in vivo

To develop a photoactivatable bioluminescence imaging technique, a set of high and efficient photoactivatable substrates for Renilla luciferase has been well designed and synthesized. Surprisingly, all of them could release the free luciferin that presented robust bioluminescent signals ex vivo and...

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Veröffentlicht in:Organic & biomolecular chemistry 2018, Vol.16 (26), p.4789-4792
Hauptverfasser: Zhang, Chaochao, Cheng, Lin, Dong, Gaopan, Han, Guangxi, Yang, Xingye, Tang, Chunchao, Li, Xiang, Zhou, Yubin, Du, Lupei, Li, Minyong
Format: Artikel
Sprache:eng
Schlagworte:
Bioluminescence
In vivo methods and tests
Irradiation
Luciferin
Substrates
Ultraviolet radiation
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Zusammenfassung:To develop a photoactivatable bioluminescence imaging technique, a set of high and efficient photoactivatable substrates for Renilla luciferase has been well designed and synthesized. Surprisingly, all of them could release the free luciferin that presented robust bioluminescent signals ex vivo and in living animals after UV irradiation at 365 nm.
ISSN:1477-0520
1477-0539
DOI:10.1039/c8ob01192c