Association of low‐density lipoprotein receptor‐related protein 1 rs11613352 and angiopoietin‐like 3 rs2131925 with hypertension in men—the Tampere adult population cardiovascular risk study

Background We examined the association of three known genome‐wide association study loci for blood lipids that have lead traits for triglycerides with hypertension in the Tampere adult population cardiovascular risk study. Methods A Finnish cohort of 190 men with diagnosed hypertension and 279 controls were analyzed. Samples were genotyped for low‐density lipoprotein receptor‐related protein 1 rs11613352 (C>T), angiopoietin‐like 3 rs2131925 (T>G), and fatty acid desaturase 1 rs174546 (C>T) polymorphisms using competitive allele‐specific polymerase chain reaction technique. Results At the age of 50, subjects with low‐density lipoprotein receptor‐related protein 1 rs11613352 (C>T) minor genotype TT had significantly more hypertension than those with the C allele (OR 5.17, CI 2.03–12.74, p G) T allele had more hypertension than those with the minor genotype GG (OR 5.02, CI 1.40–17.98, p = 0.013). Fatty acid desaturase 1 rs174546 (C>T) did not associate with hypertension. Conclusion Association of low‐density lipoprotein receptor‐related protein 1 rs11613352 and angiopoietin‐like 3 rs2131925 with hypertension might imply a direct effect at the artery wall. We examined the association of three known genome‐wide association study loci for blood lipids that have lead traits for triglycerides with hypertension in the Tampere adult population cardiovascular risk study. Association of low‐density lipoprotein receptor‐related protein 1 rs11613352 and angiopoietin‐like 3 rs2131925 with hypertension might imply a direct effect at the artery wall.