Synthesis of Curcuminoids and Evaluation of Their Cytotoxic and Antioxidant Properties

Curcumin ( ) and ten derivatives ( - ) were synthesized and evaluated as cytotoxic and antioxidant agents. The results of primary screening by Sulforhodamine B assay against five human cancer cell lines (U-251 MG, glioblastoma; PC-3, human prostatic; HCT-15, human colorectal; K562, human chronic mye...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Molecules (Basel, Switzerland) Switzerland), 2017-04, Vol.22 (4), p.633
Hauptverfasser:	Lozada-García, María Concepción, Enríquez, Raúl G, Ramírez-Apán, Teresa O, Nieto-Camacho, Antonio, Palacios-Espinosa, Juan Francisco, Custodio-Galván, Zeltzin, Soria-Arteche, Olivia, Pérez-Villanueva, Jaime
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Agents - chemical synthesis Antineoplastic Agents - pharmacology Antioxidants Antioxidants - chemical synthesis Antioxidants - pharmacology Cell Line, Tumor Cell Survival Chronic myeloid leukemia Curcumin Curcumin - analogs & derivatives Curcumin - chemical synthesis Curcumin - pharmacology Cytotoxicity Free Radical Scavengers - chemical synthesis Free Radical Scavengers - pharmacology Glioblastoma Humans Inhibitory Concentration 50 Leukemia Lung cancer Molecular Structure Myeloid leukemia Non-small cell lung carcinoma Quercetin Rats Sulforhodamine Thiobarbituric acid Tocopherol Tumor cell lines
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Curcumin ( ) and ten derivatives ( - ) were synthesized and evaluated as cytotoxic and antioxidant agents. The results of primary screening by Sulforhodamine B assay against five human cancer cell lines (U-251 MG, glioblastoma; PC-3, human prostatic; HCT-15, human colorectal; K562, human chronic myelogenous leukemia; and SKLU-1, non-small cell lung cancer) allowed us to calculate the half maximal inhibitory concentration (IC ) values for the more active compounds against HCT-15 and K562 cell lines. Compounds and were the most active against both cell lines and were more active than curcumin itself. Thiobarbituric acid reactive substances (TBARS) assay showed that has potent activity; even stronger than curcumin, α-tocopherol, and quercetin.
ISSN:	1420-3049 1420-3049
DOI:	10.3390/molecules22040633