Functionalized cyclopentanes via Sc(III)-catalyzed intramolecular enolate alkylation
We report herein the intramolecular α-tert-alkylation of unsaturated β-ketoesters which gives rise to highly functionalized cyclopentanes. This transformation is characterized by its operational simplicity, mild reaction conditions and the use of scandium (III) triflate as a Lewis acid catalyst. Of...
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Veröffentlicht in: | Tetrahedron 2018-06, Vol.74 (26), p.3306-3313 |
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Hauptverfasser: | , , , |
Format: | Artikel |
Sprache: | eng |
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Online-Zugang: | Volltext |
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Zusammenfassung: | We report herein the intramolecular α-tert-alkylation of unsaturated β-ketoesters which gives rise to highly functionalized cyclopentanes. This transformation is characterized by its operational simplicity, mild reaction conditions and the use of scandium (III) triflate as a Lewis acid catalyst. Of interest, cyclopentanes bearing heterocycles, sites for post reaction functionalization and spirocyclic architectures are accessible with this strategy.
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ISSN: | 0040-4020 1464-5416 |
DOI: | 10.1016/j.tet.2018.04.036 |