Microwave-promoted facile and efficient preparation of N-(alkoxycarbonylmethyl) nucleobases--building blocks for peptide nucleic acids

Microwave-promoted facile and efficient preparation of N-(alkoxycarbonylmethyl) nucleobases--building blocks for peptide nucleic acids

A simple, rapid, and regioselective approach for the synthesis of N-(methoxy-carbonylmethyl)- and N-(n-propoxycarbonylmethyl) nucleobases was developed. By using DMF as the solvent and in the presence of K2CO3 as the base, all the desired products were obtained in moderate yields within 8 min under...

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Veröffentlicht in:Molecules (Basel, Switzerland) Switzerland), 2007-03, Vol.12 (3), p.543-551
Hauptverfasser: Qu, Guirong, Zhang, Zhiguang, Guo, Haiming, Geng, Mingwei, Xia, Ran
Format: Artikel
Sprache:eng
Schlagworte:
Acids
Alkylation
Cytosine - analogs & derivatives
Cytosine - chemical synthesis
Cytosine - chemistry
Dimethylformamide
Microwaves
Peptide Nucleic Acids - chemistry
Peptides
Purines - chemical synthesis
Purines - chemistry
Thymine - analogs & derivatives
Thymine - chemical synthesis
Thymine - chemistry
Time Factors
Uracil - analogs & derivatives
Uracil - chemistry
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Beschreibung
Zusammenfassung:A simple, rapid, and regioselective approach for the synthesis of N-(methoxy-carbonylmethyl)- and N-(n-propoxycarbonylmethyl) nucleobases was developed. By using DMF as the solvent and in the presence of K2CO3 as the base, all the desired products were obtained in moderate yields within 8 min under microwave irradiation.
ISSN:1420-3049
1420-3049
DOI:10.3390/12030543