Cyclization of free radicals at the C-7 position of ethyl indole-2-carboxylate derivatives: an entry to a new class of Duocarmycin Analogues

Cyclization of free radicals at the C-7 position of ethyl indole-2-carboxylate derivatives: an entry to a new class of Duocarmycin Analogues

Aryl free-radicals generated at the C-7 position of ethyl indole-2-carboxylates bearing N-allyl and propargylic groups triggered intramolecular cyclizations to furnish a new class of Duocarmycin analogues, formal ethyl pyrrolo[3,2,1-ij]quinoline-2- carboxylate derivatives, through the less favorable...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Molecules (Basel, Switzerland) Switzerland), 2005-12, Vol.10 (12), p.1446-1457
Hauptverfasser: Al-Said, Naim H, Shawakfeh, Khaled Q, Abdullah, Wasim N
Format: Artikel
Sprache:eng
Schlagworte:
Alkylating Agents - chemical synthesis
Alkylating Agents - chemistry
Cyclization
Free radicals
Free Radicals - chemistry
Indoles - chemical synthesis
Indoles - chemistry
Molecular Structure
Natural products
Nitrogen
Pyrroles - chemical synthesis
Pyrroles - chemistry
Quinolines - chemistry
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:Aryl free-radicals generated at the C-7 position of ethyl indole-2-carboxylates bearing N-allyl and propargylic groups triggered intramolecular cyclizations to furnish a new class of Duocarmycin analogues, formal ethyl pyrrolo[3,2,1-ij]quinoline-2- carboxylate derivatives, through the less favorable 6-endo-trig cyclization mode.
ISSN:1420-3049
1420-3049
DOI:10.3390/10121446