Low molecular-weight gel fraction of Aloe vera exhibits gastroprotection by inducing matrix metalloproteinase-9 inhibitory activity in alcohol-induced acute gastric lesion tissues

Low molecular-weight gel fraction of Aloe vera exhibits gastroprotection by inducing matrix metalloproteinase-9 inhibitory activity in alcohol-induced acute gastric lesion tissues

Context: Aloe has been used for the prevention and cure of various diseases and symptoms including burns, injuries, oedema and pain. Objective: This study determines the specific inhibitory activity of matrix metalloproteinase (MMP)-9 induced by the low molecular-weight gel fraction of Aloe vera (L....

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Veröffentlicht in:Pharmaceutical biology 2017, Vol.55 (1), p.2110-2115
Hauptverfasser: Park, Chul-Hong, Son, Hyeong-U, Yoo, Chi-Yeol, Lee, Sang-Han
Format: Artikel
Sprache:eng
Schlagworte:
Alcohol
alcohol induction
Aloe
Aloe vera
Animals
Antiulcer activity
Body weight
Edema
Enzyme Induction - drug effects
Enzyme Induction - physiology
Ethanol - toxicity
Gastric Mucosa - drug effects
Gastric Mucosa - enzymology
Gastritis
Gastritis - chemically induced
Gastritis - enzymology
Gastritis - prevention & control
Gelatinase B
Gels
Gene expression
Immunohistochemistry
Lesions
Male
Matrix metalloproteinase
Matrix Metalloproteinase 9 - biosynthesis
Metalloproteinase
Mice
Mice, Inbred BALB C
Molecular weight
Mucosa
Plant Extracts - isolation & purification
Plant Extracts - pharmacology
Plant Extracts - therapeutic use
Polymerase chain reaction
Protein expression
Reverse transcription
Rodents
RT-PCR
Stomach Ulcer - chemically induced
Stomach Ulcer - enzymology
Stomach Ulcer - prevention & control
ulcer index
Ulcers
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Zusammenfassung:Context: Aloe has been used for the prevention and cure of various diseases and symptoms including burns, injuries, oedema and pain. Objective: This study determines the specific inhibitory activity of matrix metalloproteinase (MMP)-9 induced by the low molecular-weight gel fraction of Aloe vera (L.) Burm.f. (lgfAv) on alcohol-induced acute gastric lesions. Materials and methods: We examined the protective effects of oral (p.o.) administration of lgfAv (molecular weight cutoff
ISSN:1388-0209
1744-5116
DOI:10.1080/13880209.2017.1371770