Novel Approach to Estimate Osteoarthritis Progression: Use of the Reliable Change Index in the Evaluation of Joint Space Loss

Objective Osteoarthritis‐related changes in joint space measurements over time are small and sensitive to measurement error. The Reliable Change Index (RCI) determines whether the magnitude of change observed in an individual can be attributed to true change. This study aimed to examine the RCI as a...

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Veröffentlicht in:	Arthritis care & research (2010) 2019-02, Vol.71 (2), p.300-307
Hauptverfasser:	Parsons, Camille M., Judge, Andrew, Bruyère, Olivier, Reginster, Jean‐Yves, Dennison, Elaine M., Christiansen, C., Bellamy, N., Speirs, C., Bréart, G., Meyer, O., Arlot, M., Roux, J.‐P., Deroisy, R., Sambrook, P., Bensen, W., Hala, T., Holm‐Bentzen, M., Valter, I., Chevalier, X., Swoboda, B., Adami, S., Badurski, J., Branco, J., Nasonov, E., Navarro, F., Spector, T., Barnsley, L., Hall, S., Klestov, A., Nash, P., Will, R., Erlacher, L., Leeb, F. B., Resch, H., Rainer, F., Zamani, O., Appelboom, T., Devogelaer, J. P., Kvasz, A., Raeman, F., Verbruggen, A., Beaulieu, A. D., Bensen, W. G., Brown, J., Cividino, A. A., Morin, F., Raynauld, J. P., Pavelka, K., Alexandersen, P., Hoeck, H. C., Aim, L., Audouy, P., Beaunier, P., Berenbaum, F., Chabaud, E., Chalet, D., Cohen‐Solal, M., Delbecq, D., Fardellone, P., Hilliquin, P., Jude, N., Lechevalier, D., Schaeverbeke, T., Vignot, E., Burmester, G. R., Grifka, J., Zacher, J., Bianchi, G., Grassi, W., Di Matteo, L., Di Munno, O., Kloppenburg, M., Van Riel, P. L. C. M., Czerwinski, E., Gorecki, A., Canas Da Silva, J., Radulescu, F., Pikhlak, E. G., Shostak, N. A., Shmidt, E. I., Zagorodniy, N. V., Arboleya Rodríguez, L., Benito Ruiz, P., Collantes Estévez, E., Herrero‐Beaumont, G., Martín Mola, E., Padrino, J. M., Palacios, C., Rodríguez De La Serna, A., Torrijos, A., Abdulhakim, E., Arden, N., Birrell, F., Donnachie, H., Fraser, W., Keen, R., Stone, M. D.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Arthritis Bone Density Conservation Agents - therapeutic use Disease Progression Female General & internal medicine Human health sciences Humans Knee Knee Joint - diagnostic imaging Life Sciences Male Middle Aged Médecine générale & interne Osteoarthritis Osteoarthritis, Knee - diagnostic imaging Osteoarthritis, Knee - drug therapy Osteoarthritis, Knee - epidemiology Radiography Reproducibility of Results Sciences de la santé humaine Severity of Illness Index Strontium Thiophenes - therapeutic use
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Zusammenfassung:	Objective Osteoarthritis‐related changes in joint space measurements over time are small and sensitive to measurement error. The Reliable Change Index (RCI) determines whether the magnitude of change observed in an individual can be attributed to true change. This study aimed to examine the RCI as a novel approach to estimating osteoarthritis progression. Methods Data were from 167 men and 392 women with knee osteoarthritis (diagnosed using the American College of Rheumatology criteria) randomized to the placebo arm of the 3‐year Strontium Ranelate Efficacy in Knee Osteoarthritis trial (SEKOIA) and assessed annually. The RCI was used to determine whether the magnitude of change in joint space width (JSW) on radiographs between study years was likely to be true or due to measurement error. Results Between consecutive years, 57–69% of participants had an apparent decrease (change
ISSN:	2151-464X 0893-7524 2151-4658 2151-4658 1529-0123
DOI:	10.1002/acr.23596