Rab GTPases in Osteoclastic Endomembrane Systems

Osteoclasts (OCs) are bone-resorbing cells that maintain bone homeostasis. OC differentiation, survival, and activity are regulated by numerous small GTPases, including those of the Rab family, which are involved in plasma membrane delivery and lysosomal and autophagic degradation pathways. In resor...

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Veröffentlicht in:	BioMed research international 2018-01, Vol.2018 (2018), p.1-15
Hauptverfasser:	Roy, Michèle, Roux, Sophie
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis Autophagy Biocompatibility Biology Bone and Bones Bone Resorption Bone turnover Endosomes G proteins Genes Genetics Homeostasis Kinases Osteoclastogenesis Osteoclasts Osteoclasts - physiology Protein Transport Proteins rab GTP-Binding Proteins - physiology Review
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Beschreibung
Zusammenfassung:	Osteoclasts (OCs) are bone-resorbing cells that maintain bone homeostasis. OC differentiation, survival, and activity are regulated by numerous small GTPases, including those of the Rab family, which are involved in plasma membrane delivery and lysosomal and autophagic degradation pathways. In resorbing OCs, polarized vesicular trafficking pathways also result in formation of the ruffled membrane, the resorbing organelle, and in transcytosis.
ISSN:	2314-6133 2314-6141
DOI:	10.1155/2018/4541538