Vinylation of Benzylic Amines via C–N Bond Functionalization of Benzylic Pyridinium Salts

Vinylation of Benzylic Amines via C–N Bond Functionalization of Benzylic Pyridinium Salts

Abstract Cross-couplings of benzylic pyridinium salts and vinylboronic acids or esters have been developed. Via benzylic pyridinium intermediates, benzylic amines can be engaged in these cross-couplings through C–N bond functionalization. This method boasts mild reaction conditions and excellent tol...

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Veröffentlicht in:Synthesis (Stuttgart) 2018-08, Vol.50 (16), p.3231-3237
Hauptverfasser: Guan, Weiye, Liao, Jennie, Watson, Mary P.
Format: Artikel
Sprache:eng
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special topic
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Zusammenfassung:Abstract Cross-couplings of benzylic pyridinium salts and vinylboronic acids or esters have been developed. Via benzylic pyridinium intermediates, benzylic amines can be engaged in these cross-couplings through C–N bond functionalization. This method boasts mild reaction conditions and excellent tolerance for heteroaryl substituents and a range of functional groups.
ISSN:0039-7881
1437-210X
DOI:10.1055/s-0037-1610084