A Kelch domain-containing KLHDC7B and a long non-coding RNA ST8SIA6-AS1 act oppositely on breast cancer cell proliferation via the interferon signaling pathway

In our previous study, the Kelch domain-containing 7B (KLHDC7B) was revealed to be hypermethylated at the promoter but upregulated in breast cancer. In this study, we identified a long non-coding RNA, ST8SIA6-AS1 (STAR1), whose expression was significantly associated with KLHDC7B in breast cancer (...

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Veröffentlicht in:	Scientific reports 2018-08, Vol.8 (1), p.12922-10, Article 12922
Hauptverfasser:	Jeong, Gookjoo, Bae, Hansol, Jeong, Dawoon, Ham, Juyeon, Park, Sungbin, Kim, Hyeon Woo, Kang, Han-Sung, Kim, Sun Jung
Format:	Artikel
Sprache:	eng
Schlagworte:	13 13/2 13/95 38 38/77 38/89 45 45/61 631/337/384/2568 631/67/1347 Adaptor Proteins, Signal Transducing Apoptosis Breast cancer Breast Neoplasms - genetics Breast Neoplasms - metabolism Carrier Proteins - genetics Carrier Proteins - metabolism Cell adhesion & migration Cell Line, Tumor Cell migration Cell Movement - genetics Cell Movement - physiology Cell proliferation Cell Proliferation - genetics Cell Proliferation - physiology Flow Cytometry Gene Expression Regulation, Neoplastic - genetics Gene Expression Regulation, Neoplastic - physiology Genes Humanities and Social Sciences Humans Interferon Interferons - genetics Interferons - metabolism Interleukins - genetics Interleukins - metabolism MCF-7 Cells multidisciplinary Non-coding RNA Reverse Transcriptase Polymerase Chain Reaction RNA, Long Noncoding - genetics RNA, Long Noncoding - metabolism RNA-Binding Proteins Science Science (multidisciplinary) Signal transduction Signal Transduction - genetics Signal Transduction - physiology STAT Transcription Factors - genetics STAT Transcription Factors - metabolism Tumorigenesis
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Zusammenfassung:	In our previous study, the Kelch domain-containing 7B (KLHDC7B) was revealed to be hypermethylated at the promoter but upregulated in breast cancer. In this study, we identified a long non-coding RNA, ST8SIA6-AS1 (STAR1), whose expression was significantly associated with KLHDC7B in breast cancer ( R 2 = 0.3466, P
ISSN:	2045-2322 2045-2322
DOI:	10.1038/s41598-018-31306-8