The Association between Plasma Levels of Trimethylamine N-Oxide and the Risk of Coronary Heart Disease in Chinese Patients with or without Type 2 Diabetes Mellitus

The Association between Plasma Levels of Trimethylamine N-Oxide and the Risk of Coronary Heart Disease in Chinese Patients with or without Type 2 Diabetes Mellitus

Aim. Trimethylamine N-oxide (TMAO) has been demonstrated as an independent risk factor for cardiovascular disease. Our objective was to determine the plasma levels of TMAO in Chinese coronary heart disease (CHD) patients with or without type 2 diabetes mellitus (T2DM). Methods. A total of 132 contro...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Disease markers 2018-01, Vol.2018 (2018), p.1-7
Hauptverfasser: Shen, Zhaoqian, Hu, Shuang, Guo, Meihua, Liang, Zhaoguang, Dong, Zengxiang, Hai, Xin
Format: Artikel
Sprache:eng
Schlagworte:
Aged
Atherosclerosis
Calcium-binding protein
Cardiovascular disease
Cardiovascular diseases
China
Coronary artery disease
Coronary Disease - blood
Coronary Disease - metabolism
Coronary heart disease
Creatine
Creatine kinase
Creatine Kinase, MB Form - metabolism
Diabetes
Diabetes mellitus
Diabetes mellitus (non-insulin dependent)
Diabetes Mellitus, Type 2 - blood
Diabetes Mellitus, Type 2 - complications
Diabetes Mellitus, Type 2 - metabolism
Diabetes therapy
Disease prevention
Ethylenediaminetetraacetic acid
Female
Health risks
Heart diseases
Humans
Lipids
Lipoproteins
Male
Medical research
Medicine, Experimental
Metabolism
Metabolites
Methylamines - blood
Microbiota
Middle Aged
Mortality
Patients
Plasma levels
Regression analysis
Risk analysis
Risk Factors
ROC Curve
Standard deviation
Studies
Trimethylamine
Troponin
Troponin I
Troponin I - metabolism
Type 2 diabetes
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:Aim. Trimethylamine N-oxide (TMAO) has been demonstrated as an independent risk factor for cardiovascular disease. Our objective was to determine the plasma levels of TMAO in Chinese coronary heart disease (CHD) patients with or without type 2 diabetes mellitus (T2DM). Methods. A total of 132 control participants, 243 CHD patients, and 175 CHD patients with T2DM were enrolled. Plasma levels of TMAO in all patients were measured and analyzed. Results. The plasma levels of TMAO were significantly higher in CHD patients than in control subjects (3.08 ± 0.13 μM versus 1.49 ± 0.05 μM; P
ISSN:0278-0240
1875-8630
DOI:10.1155/2018/1578320