Evaluation of the Bactericidal Activity of Plazomicin and Comparators against Multidrug-Resistant Enterobacteriaceae
The next-generation aminoglycoside plazomicin, in development for infections due to multidrug-resistant (MDR) , was evaluated alongside comparators for bactericidal activity in minimum bactericidal concentration (MBC) and time-kill (TK) assays against MDR isolates with characterized aminoglycoside a...
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| Veröffentlicht in: | Antimicrobial agents and chemotherapy 2018-08, Vol.62 (8) |
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| container_title | Antimicrobial agents and chemotherapy |
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| creator | Thwaites, M Hall, D Shinabarger, D Serio, A W Krause, K M Marra, A Pillar, C |
| description | The next-generation aminoglycoside plazomicin, in development for infections due to multidrug-resistant (MDR)
, was evaluated alongside comparators for bactericidal activity in minimum bactericidal concentration (MBC) and time-kill (TK) assays against MDR
isolates with characterized aminoglycoside and β-lactam resistance mechanisms. Overall, plazomicin and colistin were the most potent, with plazomicin demonstrating an MBC
of 0.5/4 μg/ml and sustained 3-log
kill against MDR
,
, and
spp. |
| doi_str_mv | 10.1128/AAC.00236-18 |
| format | Article |
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, was evaluated alongside comparators for bactericidal activity in minimum bactericidal concentration (MBC) and time-kill (TK) assays against MDR
isolates with characterized aminoglycoside and β-lactam resistance mechanisms. Overall, plazomicin and colistin were the most potent, with plazomicin demonstrating an MBC
of 0.5/4 μg/ml and sustained 3-log
kill against MDR
,
, and
spp.</description><identifier>ISSN: 0066-4804</identifier><identifier>EISSN: 1098-6596</identifier><identifier>DOI: 10.1128/AAC.00236-18</identifier><identifier>PMID: 29866876</identifier><language>eng</language><publisher>United States: American Society for Microbiology</publisher><subject>Anti-Bacterial Agents ; Clinical Therapeutics ; Drug Resistance, Multiple, Bacterial ; Enterobacter ; Escherichia coli ; Klebsiella pneumoniae ; Sisomicin</subject><ispartof>Antimicrobial agents and chemotherapy, 2018-08, Vol.62 (8)</ispartof><rights>Copyright © 2018 Thwaites et al.</rights><rights>Copyright © 2018 Thwaites et al. 2018 Thwaites et al.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a3338-f5fafc2be59bc11e122b13b3bcdf1d34c6d2535a8af5d8e9ba839c72a598d4083</citedby><cites>FETCH-LOGICAL-a3338-f5fafc2be59bc11e122b13b3bcdf1d34c6d2535a8af5d8e9ba839c72a598d4083</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6105851/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6105851/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29866876$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Thwaites, M</creatorcontrib><creatorcontrib>Hall, D</creatorcontrib><creatorcontrib>Shinabarger, D</creatorcontrib><creatorcontrib>Serio, A W</creatorcontrib><creatorcontrib>Krause, K M</creatorcontrib><creatorcontrib>Marra, A</creatorcontrib><creatorcontrib>Pillar, C</creatorcontrib><title>Evaluation of the Bactericidal Activity of Plazomicin and Comparators against Multidrug-Resistant Enterobacteriaceae</title><title>Antimicrobial agents and chemotherapy</title><addtitle>Antimicrob Agents Chemother</addtitle><addtitle>Antimicrob Agents Chemother</addtitle><description>The next-generation aminoglycoside plazomicin, in development for infections due to multidrug-resistant (MDR)
, was evaluated alongside comparators for bactericidal activity in minimum bactericidal concentration (MBC) and time-kill (TK) assays against MDR
isolates with characterized aminoglycoside and β-lactam resistance mechanisms. Overall, plazomicin and colistin were the most potent, with plazomicin demonstrating an MBC
of 0.5/4 μg/ml and sustained 3-log
kill against MDR
,
, and
spp.</description><subject>Anti-Bacterial Agents</subject><subject>Clinical Therapeutics</subject><subject>Drug Resistance, Multiple, Bacterial</subject><subject>Enterobacter</subject><subject>Escherichia coli</subject><subject>Klebsiella pneumoniae</subject><subject>Sisomicin</subject><issn>0066-4804</issn><issn>1098-6596</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><recordid>eNp1kUtPGzEUhS3UClLKjnXlZSt1wI-x49lUClH6kEBUVVlbd2xPMJqxU9sTCX59Jw0gumB1dXWOvvs4CJ1SckYpU-eLxfKMEMZlRdUBmlHSqEqKRr5BM0KkrGpF6iP0Luc7MvWiIYfoiDVKSjWXM1RWW-hHKD4GHDtcbh2-AFNc8sZb6PHCFL_15X4n_uzhIQ6TEDAEi5dx2ECCElPGsAYfcsFXY1-8TeO6-uWyzwVCwasw4WK7p4Jx4N6jtx302Z081mN083X1e_m9urz-9mO5uKyAc66qTnTQGdY60bSGUkcZaylveWtsRy2vjbRMcAEKOmGVa1pQvDFzBqJRtiaKH6Mve-5mbAdnjQslQa83yQ-Q7nUEr_9Xgr_V67jVkhKhBJ0AHx8BKf4ZXS568Nm4vofg4pg1I4LUaj7nZLJ-3ltNijkn1z2PoUTvgtJTUPpfUJruVvu0t0MemL6LYwrTJ17zfnh5xjP4KUX-F57Snow</recordid><startdate>20180801</startdate><enddate>20180801</enddate><creator>Thwaites, M</creator><creator>Hall, D</creator><creator>Shinabarger, D</creator><creator>Serio, A W</creator><creator>Krause, K M</creator><creator>Marra, A</creator><creator>Pillar, C</creator><general>American Society for Microbiology</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20180801</creationdate><title>Evaluation of the Bactericidal Activity of Plazomicin and Comparators against Multidrug-Resistant Enterobacteriaceae</title><author>Thwaites, M ; Hall, D ; Shinabarger, D ; Serio, A W ; Krause, K M ; Marra, A ; Pillar, C</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a3338-f5fafc2be59bc11e122b13b3bcdf1d34c6d2535a8af5d8e9ba839c72a598d4083</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Anti-Bacterial Agents</topic><topic>Clinical Therapeutics</topic><topic>Drug Resistance, Multiple, Bacterial</topic><topic>Enterobacter</topic><topic>Escherichia coli</topic><topic>Klebsiella pneumoniae</topic><topic>Sisomicin</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Thwaites, M</creatorcontrib><creatorcontrib>Hall, D</creatorcontrib><creatorcontrib>Shinabarger, D</creatorcontrib><creatorcontrib>Serio, A W</creatorcontrib><creatorcontrib>Krause, K M</creatorcontrib><creatorcontrib>Marra, A</creatorcontrib><creatorcontrib>Pillar, C</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Antimicrobial agents and chemotherapy</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Thwaites, M</au><au>Hall, D</au><au>Shinabarger, D</au><au>Serio, A W</au><au>Krause, K M</au><au>Marra, A</au><au>Pillar, C</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Evaluation of the Bactericidal Activity of Plazomicin and Comparators against Multidrug-Resistant Enterobacteriaceae</atitle><jtitle>Antimicrobial agents and chemotherapy</jtitle><stitle>Antimicrob Agents Chemother</stitle><addtitle>Antimicrob Agents Chemother</addtitle><date>2018-08-01</date><risdate>2018</risdate><volume>62</volume><issue>8</issue><issn>0066-4804</issn><eissn>1098-6596</eissn><abstract>The next-generation aminoglycoside plazomicin, in development for infections due to multidrug-resistant (MDR)
, was evaluated alongside comparators for bactericidal activity in minimum bactericidal concentration (MBC) and time-kill (TK) assays against MDR
isolates with characterized aminoglycoside and β-lactam resistance mechanisms. Overall, plazomicin and colistin were the most potent, with plazomicin demonstrating an MBC
of 0.5/4 μg/ml and sustained 3-log
kill against MDR
,
, and
spp.</abstract><cop>United States</cop><pub>American Society for Microbiology</pub><pmid>29866876</pmid><doi>10.1128/AAC.00236-18</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| language | eng |
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| source | EZB-FREE-00999 freely available EZB journals; PubMed Central |
| subjects | Anti-Bacterial Agents Clinical Therapeutics Drug Resistance, Multiple, Bacterial Enterobacter Escherichia coli Klebsiella pneumoniae Sisomicin |
| title | Evaluation of the Bactericidal Activity of Plazomicin and Comparators against Multidrug-Resistant Enterobacteriaceae |
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