Evaluation of the Bactericidal Activity of Plazomicin and Comparators against Multidrug-Resistant Enterobacteriaceae

Evaluation of the Bactericidal Activity of Plazomicin and Comparators against Multidrug-Resistant Enterobacteriaceae

The next-generation aminoglycoside plazomicin, in development for infections due to multidrug-resistant (MDR) , was evaluated alongside comparators for bactericidal activity in minimum bactericidal concentration (MBC) and time-kill (TK) assays against MDR isolates with characterized aminoglycoside a...

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Veröffentlicht in:Antimicrobial agents and chemotherapy 2018-08, Vol.62 (8)
Hauptverfasser: Thwaites, M, Hall, D, Shinabarger, D, Serio, A W, Krause, K M, Marra, A, Pillar, C
Format: Artikel
Sprache:eng
Schlagworte:
Anti-Bacterial Agents
Clinical Therapeutics
Drug Resistance, Multiple, Bacterial
Enterobacter
Escherichia coli
Klebsiella pneumoniae
Sisomicin
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Zusammenfassung:The next-generation aminoglycoside plazomicin, in development for infections due to multidrug-resistant (MDR) , was evaluated alongside comparators for bactericidal activity in minimum bactericidal concentration (MBC) and time-kill (TK) assays against MDR isolates with characterized aminoglycoside and β-lactam resistance mechanisms. Overall, plazomicin and colistin were the most potent, with plazomicin demonstrating an MBC of 0.5/4 μg/ml and sustained 3-log kill against MDR , , and spp.
ISSN:0066-4804
1098-6596
DOI:10.1128/AAC.00236-18