In Vitro and In Vivo Activities of Contezolid (MRX-I) against Mycobacterium tuberculosis

In Vitro and In Vivo Activities of Contezolid (MRX-I) against Mycobacterium tuberculosis

The activity of contezolid (MRX-I) against clinical isolates of was evaluated using a microtiter broth dilution assay. MRX-I was as effective as linezolid (LZD) MRX-I and LZD were subsequently studied in BALB/c mice infected intranasally with Erdman. MRX-I and LZD at 100 mg/kg significantly reduced...

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Veröffentlicht in:Antimicrobial agents and chemotherapy 2018-08, Vol.62 (8)
Hauptverfasser: Shoen, Carolyn, DeStefano, Michelle, Hafkin, Barry, Cynamon, Michael
Format: Artikel
Sprache:eng
Schlagworte:
Antitubercular Agents
Experimental Therapeutics
Mycobacterium tuberculosis
Oxazolidinones
Pyridones
Tuberculosis, Multidrug-Resistant
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Zusammenfassung:The activity of contezolid (MRX-I) against clinical isolates of was evaluated using a microtiter broth dilution assay. MRX-I was as effective as linezolid (LZD) MRX-I and LZD were subsequently studied in BALB/c mice infected intranasally with Erdman. MRX-I and LZD at 100 mg/kg significantly reduced the bacterial load in lungs compared to the untreated early and late controls.
ISSN:0066-4804
1098-6596
DOI:10.1128/AAC.00493-18