Biocatalytic Oxidation Reactions: A Chemist's Perspective

Oxidation chemistry using enzymes is approaching maturity and practical applicability in organic synthesis. Oxidoreductases (enzymes catalysing redox reactions) enable chemists to perform highly selective and efficient transformations ranging from simple alcohol oxidations to stereoselective halogen...

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Veröffentlicht in:Angewandte Chemie International Edition 2018-07, Vol.57 (30), p.9238-9261
Hauptverfasser: Dong, JiaJia, Fernández‐Fueyo, Elena, Hollmann, Frank, Paul, Caroline E., Pesic, Milja, Schmidt, Sandy, Wang, Yonghua, Younes, Sabry, Zhang, Wuyuan
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Sprache:eng
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Zusammenfassung:Oxidation chemistry using enzymes is approaching maturity and practical applicability in organic synthesis. Oxidoreductases (enzymes catalysing redox reactions) enable chemists to perform highly selective and efficient transformations ranging from simple alcohol oxidations to stereoselective halogenations of non‐activated C−H bonds. For many of these reactions, no “classical” chemical counterpart is known. Hence oxidoreductases open up shorter synthesis routes based on a more direct access to the target products. The generally very mild reaction conditions may also reduce the environmental impact of biocatalytic reactions compared to classical counterparts. In this Review, we critically summarise the most important recent developments in the field of biocatalytic oxidation chemistry and identify the most pressing bottlenecks as well as promising solutions. Oxidoreductases enable highly selective and efficient transformations, ranging from simple alcohol oxidations to stereoselective halogenations of non‐activated C−H bonds. This Review summarises the most important recent developments in the field of biocatalytic oxidation chemistry and identifies the most pressing bottlenecks as well as promising solutions.
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.201800343