High Incidence of Tuberculosis Infection in HIV-exposed Children Exiting an Isoniazid Preventive Therapy Trial

High Incidence of Tuberculosis Infection in HIV-exposed Children Exiting an Isoniazid Preventive Therapy Trial

Young HIV-exposed children are at high risk for TB infection. We performed QuantiFERON-TB Gold among HIV-exposed children in South Africa at enrolment and 1-year follow-up. The incidence of TB infection was high for HIV+ (11 cases per 100 child-years) and HIV-exposed uninfected children (15 cases pe...

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Veröffentlicht in:The Pediatric infectious disease journal 2018-10, Vol.37 (10), p.e254-e256
Hauptverfasser: Cranmer, Lisa M, Draper, Heather R, Mandalakas, Anna M, Kim, Soyeon, McSherry, George, Krezinski, Emma, Coetzee, Joan, Mitchell, Charles, Nachman, Sharon, van der Linde, Mercia, Cotton, Mark F, Hesseling, Anneke C
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Sprache:eng
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Zusammenfassung:Young HIV-exposed children are at high risk for TB infection. We performed QuantiFERON-TB Gold among HIV-exposed children in South Africa at enrolment and 1-year follow-up. The incidence of TB infection was high for HIV+ (11 cases per 100 child-years) and HIV-exposed uninfected children (15 cases per 100 child-years). QuantiFERON-TB Gold may identify HIV-exposed children at risk for TB disease progression.
ISSN:0891-3668
1532-0987
DOI:10.1097/INF.0000000000001946