Plasma Homoarginine Concentrations According to Use of Hormonal Contraception
Estrogen is a potent vasodilator through activation of endothelial nitric oxide synthase (eNOS). Arginine and its homologue homoarginine are substrates for NOS, while asymmetric dimethylarginine (ADMA) is a NOS inhibitor. Healthy, never-pregnant women aged 18 to 40 years (n = 158) were categorized a...
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| Veröffentlicht in: | Scientific reports 2018-08, Vol.8 (1), p.12217-7, Article 12217 |
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| description | Estrogen is a potent vasodilator through activation of endothelial nitric oxide synthase (eNOS). Arginine and its homologue homoarginine are substrates for NOS, while asymmetric dimethylarginine (ADMA) is a NOS inhibitor. Healthy, never-pregnant women aged 18 to 40 years (n = 158) were categorized according to use of hormonal contraception into non-users (n = 76), users of estrogen contraceptives (EC-users, n = 58) and users of progestins-only contraceptives (PC-users, n = 24). Plasma homoarginine, arginine, ADMA and SDMA concentrations were assayed using a LC-MS/MS method. Compared to non-users, EC users had higher plasma homoarginine (median (interquartile range) 1.63 (1.24, 2.04) vs. 2.39 (2.05, 2.85) µmol/L, p |
| doi_str_mv | 10.1038/s41598-018-30708-y |
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Arginine and its homologue homoarginine are substrates for NOS, while asymmetric dimethylarginine (ADMA) is a NOS inhibitor. Healthy, never-pregnant women aged 18 to 40 years (n = 158) were categorized according to use of hormonal contraception into non-users (n = 76), users of estrogen contraceptives (EC-users, n = 58) and users of progestins-only contraceptives (PC-users, n = 24). Plasma homoarginine, arginine, ADMA and SDMA concentrations were assayed using a LC-MS/MS method. Compared to non-users, EC users had higher plasma homoarginine (median (interquartile range) 1.63 (1.24, 2.04) vs. 2.39 (2.05, 2.85) µmol/L, p < 0.001), lower arginine (80.8 (72.4, 94.3) vs. 72.1 (62.9, 85.1) µmol/L, p = 0.008) and ADMA (0.52 (0.46, 0.59) vs. 0.48 (0.42, 0.54) µmol/L, p = 0.003) concentrations. The lowest median plasma homoarginine concentration (1.34 (0.92, 1.75) µmol) was seen in PC-users. No differences were seen in SDMA concentrations according to use of hormonal contraception. In healthy, never-pregnant women aged 18 to 40 years, use of estrogen containing contraception was associated with significantly higher plasma concentrations of homoarginine and lower plasma concentrations of arginine and ADMA as compared to non-users, while the lowest plasma homoarginine concentrations were seen in progestin-only users. Whether the observed changes in relation to use of hormonal contraception have an impact on cardiovascular status, should be evaluated in an intervention study.</description><identifier>ISSN: 2045-2322</identifier><identifier>EISSN: 2045-2322</identifier><identifier>DOI: 10.1038/s41598-018-30708-y</identifier><identifier>PMID: 30111829</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>631/443/319/1642/2037 ; 692/53/2422 ; 82/58 ; Arginine ; Birth control ; Contraception ; Contraceptives ; Estrogens ; Humanities and Social Sciences ; multidisciplinary ; Nitric oxide ; Nitric-oxide synthase ; Pregnancy ; Progestin ; Science ; Science (multidisciplinary)</subject><ispartof>Scientific reports, 2018-08, Vol.8 (1), p.12217-7, Article 12217</ispartof><rights>The Author(s) 2018</rights><rights>2018. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c522t-f7a0a89d039b0c3d2b33044038615b38139e6422a71bbf5619c6a75cbd09b1b33</citedby><cites>FETCH-LOGICAL-c522t-f7a0a89d039b0c3d2b33044038615b38139e6422a71bbf5619c6a75cbd09b1b33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6093891/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6093891/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,315,728,781,785,865,886,27929,27930,41125,42194,51581,53796,53798</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30111829$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Helm, Thea</creatorcontrib><creatorcontrib>Varsi, Kristin</creatorcontrib><creatorcontrib>Fløtre, Christina Herland</creatorcontrib><creatorcontrib>Lund, Agnethe</creatorcontrib><creatorcontrib>Svingen, Gard Frodahl Tveitevåg</creatorcontrib><creatorcontrib>Ueland, Per Magne</creatorcontrib><creatorcontrib>Bjørke-Monsen, Anne-Lise</creatorcontrib><title>Plasma Homoarginine Concentrations According to Use of Hormonal Contraception</title><title>Scientific reports</title><addtitle>Sci Rep</addtitle><addtitle>Sci Rep</addtitle><description>Estrogen is a potent vasodilator through activation of endothelial nitric oxide synthase (eNOS). Arginine and its homologue homoarginine are substrates for NOS, while asymmetric dimethylarginine (ADMA) is a NOS inhibitor. Healthy, never-pregnant women aged 18 to 40 years (n = 158) were categorized according to use of hormonal contraception into non-users (n = 76), users of estrogen contraceptives (EC-users, n = 58) and users of progestins-only contraceptives (PC-users, n = 24). Plasma homoarginine, arginine, ADMA and SDMA concentrations were assayed using a LC-MS/MS method. Compared to non-users, EC users had higher plasma homoarginine (median (interquartile range) 1.63 (1.24, 2.04) vs. 2.39 (2.05, 2.85) µmol/L, p < 0.001), lower arginine (80.8 (72.4, 94.3) vs. 72.1 (62.9, 85.1) µmol/L, p = 0.008) and ADMA (0.52 (0.46, 0.59) vs. 0.48 (0.42, 0.54) µmol/L, p = 0.003) concentrations. The lowest median plasma homoarginine concentration (1.34 (0.92, 1.75) µmol) was seen in PC-users. No differences were seen in SDMA concentrations according to use of hormonal contraception. In healthy, never-pregnant women aged 18 to 40 years, use of estrogen containing contraception was associated with significantly higher plasma concentrations of homoarginine and lower plasma concentrations of arginine and ADMA as compared to non-users, while the lowest plasma homoarginine concentrations were seen in progestin-only users. Whether the observed changes in relation to use of hormonal contraception have an impact on cardiovascular status, should be evaluated in an intervention study.</description><subject>631/443/319/1642/2037</subject><subject>692/53/2422</subject><subject>82/58</subject><subject>Arginine</subject><subject>Birth control</subject><subject>Contraception</subject><subject>Contraceptives</subject><subject>Estrogens</subject><subject>Humanities and Social Sciences</subject><subject>multidisciplinary</subject><subject>Nitric oxide</subject><subject>Nitric-oxide synthase</subject><subject>Pregnancy</subject><subject>Progestin</subject><subject>Science</subject><subject>Science (multidisciplinary)</subject><issn>2045-2322</issn><issn>2045-2322</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp9kUtLxDAUhYMoKuP8ARdScOOmepP0kWwEGdQRFF0465Cmaa20yZi0wvx7U-t7YbJI4H733Hs4CB1iOMVA2ZlPcMpZDJjFFHJg8WYL7RNI0phQQrZ__PfQ3PtnCCclPMF8F-1RwBgzwvfR3UMrfSejpe2sdHVjGqOjhTVKm97JvrHGRxdKWVc2po56G628jmwVeNdZI9uRDaDS65E9QDuVbL2ef7wztLq6fFws49v765vFxW2sUkL6uMolSMZLoLwARUtSUApJEmxlOC0ow5TrLCFE5rgoqjTDXGUyT1VRAi9wgGfofNJdD0Wny2nZVqxd00m3EVY24nfFNE-itq8iA04Zx0Hg5EPA2ZdB-150jVe6baXRdvCCAOOEQ7gBPf6DPtvBBevvFMsZcD5uRCZKOeu909XXMhjEGJiYAhMhMPEemNiEpqOfNr5aPuMJAJ0AH0qm1u579j-yb3INoWw</recordid><startdate>20180815</startdate><enddate>20180815</enddate><creator>Helm, Thea</creator><creator>Varsi, Kristin</creator><creator>Fløtre, Christina Herland</creator><creator>Lund, Agnethe</creator><creator>Svingen, Gard Frodahl Tveitevåg</creator><creator>Ueland, Per Magne</creator><creator>Bjørke-Monsen, Anne-Lise</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>C6C</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>88I</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20180815</creationdate><title>Plasma Homoarginine Concentrations According to Use of Hormonal Contraception</title><author>Helm, Thea ; 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Arginine and its homologue homoarginine are substrates for NOS, while asymmetric dimethylarginine (ADMA) is a NOS inhibitor. Healthy, never-pregnant women aged 18 to 40 years (n = 158) were categorized according to use of hormonal contraception into non-users (n = 76), users of estrogen contraceptives (EC-users, n = 58) and users of progestins-only contraceptives (PC-users, n = 24). Plasma homoarginine, arginine, ADMA and SDMA concentrations were assayed using a LC-MS/MS method. Compared to non-users, EC users had higher plasma homoarginine (median (interquartile range) 1.63 (1.24, 2.04) vs. 2.39 (2.05, 2.85) µmol/L, p < 0.001), lower arginine (80.8 (72.4, 94.3) vs. 72.1 (62.9, 85.1) µmol/L, p = 0.008) and ADMA (0.52 (0.46, 0.59) vs. 0.48 (0.42, 0.54) µmol/L, p = 0.003) concentrations. The lowest median plasma homoarginine concentration (1.34 (0.92, 1.75) µmol) was seen in PC-users. No differences were seen in SDMA concentrations according to use of hormonal contraception. In healthy, never-pregnant women aged 18 to 40 years, use of estrogen containing contraception was associated with significantly higher plasma concentrations of homoarginine and lower plasma concentrations of arginine and ADMA as compared to non-users, while the lowest plasma homoarginine concentrations were seen in progestin-only users. Whether the observed changes in relation to use of hormonal contraception have an impact on cardiovascular status, should be evaluated in an intervention study.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>30111829</pmid><doi>10.1038/s41598-018-30708-y</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | 631/443/319/1642/2037 692/53/2422 82/58 Arginine Birth control Contraception Contraceptives Estrogens Humanities and Social Sciences multidisciplinary Nitric oxide Nitric-oxide synthase Pregnancy Progestin Science Science (multidisciplinary) |
| title | Plasma Homoarginine Concentrations According to Use of Hormonal Contraception |
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