Plasma Homoarginine Concentrations According to Use of Hormonal Contraception

Plasma Homoarginine Concentrations According to Use of Hormonal Contraception

Estrogen is a potent vasodilator through activation of endothelial nitric oxide synthase (eNOS). Arginine and its homologue homoarginine are substrates for NOS, while asymmetric dimethylarginine (ADMA) is a NOS inhibitor. Healthy, never-pregnant women aged 18 to 40 years (n = 158) were categorized a...

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Veröffentlicht in:Scientific reports 2018-08, Vol.8 (1), p.12217-7, Article 12217
Hauptverfasser: Helm, Thea, Varsi, Kristin, Fløtre, Christina Herland, Lund, Agnethe, Svingen, Gard Frodahl Tveitevåg, Ueland, Per Magne, Bjørke-Monsen, Anne-Lise
Format: Artikel
Sprache:eng
Schlagworte:
631/443/319/1642/2037
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Arginine
Birth control
Contraception
Contraceptives
Estrogens
Humanities and Social Sciences
multidisciplinary
Nitric oxide
Nitric-oxide synthase
Pregnancy
Progestin
Science
Science (multidisciplinary)
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Zusammenfassung:Estrogen is a potent vasodilator through activation of endothelial nitric oxide synthase (eNOS). Arginine and its homologue homoarginine are substrates for NOS, while asymmetric dimethylarginine (ADMA) is a NOS inhibitor. Healthy, never-pregnant women aged 18 to 40 years (n = 158) were categorized according to use of hormonal contraception into non-users (n = 76), users of estrogen contraceptives (EC-users, n = 58) and users of progestins-only contraceptives (PC-users, n = 24). Plasma homoarginine, arginine, ADMA and SDMA concentrations were assayed using a LC-MS/MS method. Compared to non-users, EC users had higher plasma homoarginine (median (interquartile range) 1.63 (1.24, 2.04) vs. 2.39 (2.05, 2.85) µmol/L, p 
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-018-30708-y