Genetic Vulnerability of GPCRs: A Call to Action
G-protein-coupled receptors (GPCRs) are the targets for many drugs, but the response shows interindividual variability. The ‘one-drug-fits-all’ approach has been challenged by evidence showing multiple human genetic variants of GPCRs. Identification and characterization of GPCR variants must be unde...
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| Veröffentlicht in: | Trends in biochemical sciences (Amsterdam. Regular ed.) 2018-04, Vol.43 (4), p.227-229 |
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| container_title | Trends in biochemical sciences (Amsterdam. Regular ed.) |
| container_volume | 43 |
| creator | Liggett, Stephen B. |
| description | G-protein-coupled receptors (GPCRs) are the targets for many drugs, but the response shows interindividual variability. The ‘one-drug-fits-all’ approach has been challenged by evidence showing multiple human genetic variants of GPCRs. Identification and characterization of GPCR variants must be undertaken for rational, personalized, and economically sound prescribing practices. |
| doi_str_mv | 10.1016/j.tibs.2018.02.006 |
| format | Article |
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| fulltext | fulltext |
| identifier | ISSN: 0968-0004 |
| ispartof | Trends in biochemical sciences (Amsterdam. Regular ed.), 2018-04, Vol.43 (4), p.227-229 |
| issn | 0968-0004 1362-4326 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6092946 |
| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | asthma coupling G protein Genetic Variation heart failure Humans Mutation polymorphism Receptors, G-Protein-Coupled - genetics |
| title | Genetic Vulnerability of GPCRs: A Call to Action |
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