Genetic Vulnerability of GPCRs: A Call to Action

Genetic Vulnerability of GPCRs: A Call to Action

G-protein-coupled receptors (GPCRs) are the targets for many drugs, but the response shows interindividual variability. The ‘one-drug-fits-all’ approach has been challenged by evidence showing multiple human genetic variants of GPCRs. Identification and characterization of GPCR variants must be unde...

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Veröffentlicht in:Trends in biochemical sciences (Amsterdam. Regular ed.) 2018-04, Vol.43 (4), p.227-229
1. Verfasser: Liggett, Stephen B.
Format: Artikel
Sprache:eng
Schlagworte:
asthma
coupling
G protein
Genetic Variation
heart failure
Humans
Mutation
polymorphism
Receptors, G-Protein-Coupled - genetics
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Zusammenfassung:G-protein-coupled receptors (GPCRs) are the targets for many drugs, but the response shows interindividual variability. The ‘one-drug-fits-all’ approach has been challenged by evidence showing multiple human genetic variants of GPCRs. Identification and characterization of GPCR variants must be undertaken for rational, personalized, and economically sound prescribing practices.
ISSN:0968-0004
1362-4326
DOI:10.1016/j.tibs.2018.02.006