Delayed Presentation of Isolated Adrenocorticotropin Insufficiency after Nivolumab Therapy for Advanced Non-small-cell lung carcinoma (NSCLC)

Delayed Presentation of Isolated Adrenocorticotropin Insufficiency after Nivolumab Therapy for Advanced Non-small-cell lung carcinoma (NSCLC)

We describe a 73-year-old man who developed adrenal insufficiency 7 months after completing nivolumab therapy for advanced non-small cell lung cancer. He presented with non-specific symptoms of malaise and fatigue with an insidious 13.6 kilogram weight loss, prompting an evaluation for disease progr...

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Veröffentlicht in:BMJ case reports 2018-08, Vol.2018, p.bcr-2018-225048
Hauptverfasser: Shrotriya, Shiva, Rai, Manoj P, Alratroot, Ahmad, Sarzynski, Erin
Format: Artikel
Sprache:eng
Schlagworte:
Adrenal glands
Case reports
Family medical history
Hormones
Immunotherapy
Insulin-like growth factors
Laboratories
Lung cancer
Melanoma
Metastasis
Monoclonal antibodies
Patients
Potassium
Skin cancer
Systematic review
Targeted cancer therapy
Thyroid gland
Unexpected Outcome (Positive or Negative) Including Adverse Drug Reactions
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Zusammenfassung:We describe a 73-year-old man who developed adrenal insufficiency 7 months after completing nivolumab therapy for advanced non-small cell lung cancer. He presented with non-specific symptoms of malaise and fatigue with an insidious 13.6 kilogram weight loss, prompting an evaluation for disease progression, which was negative. Subsequent evaluation revealed isolated adrenocorticotropin insufficiency as the aetiology, attributed to a delayed side effect of nivolumab therapy.
ISSN:1757-790X
1757-790X
DOI:10.1136/bcr-2018-225048