Direct Visualization of the Conformational Dynamics of Single Influenza Hemagglutinin Trimers

Influenza hemagglutinin (HA) is the canonical type I viral envelope glycoprotein and provides a template for the membrane-fusion mechanisms of numerous viruses. The current model of HA-mediated membrane fusion describes a static “spring-loaded” fusion domain (HA2) at neutral pH. Acidic pH triggers a...

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Veröffentlicht in:	Cell 2018-08, Vol.174 (4), p.926-937.e12
Hauptverfasser:	Das, Dibyendu Kumar, Govindan, Ramesh, Nikić-Spiegel, Ivana, Krammer, Florian, Lemke, Edward A., Munro, James B.
Format:	Artikel
Sprache:	eng
Schlagworte:	A549 Cells Cell Membrane - metabolism Fluorescence Resonance Energy Transfer - methods HEK293 Cells Hemagglutinin Glycoproteins, Influenza Virus - chemistry Hemagglutinin Glycoproteins, Influenza Virus - metabolism Hemagglutinins - metabolism Humans Hydrogen-Ion Concentration Influenza A virus - physiology Influenza, Human - metabolism Influenza, Human - virology membrane fusion Protein Binding Protein Conformation protein dynamics Single Molecule Imaging - methods single-molecule fluorescence smFRET virus entry Virus Internalization
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