Oral Tecovirimat for the Treatment of Smallpox

There are no FDA-approved antiviral agents to treat infection with variola virus, the cause of smallpox. In this report, the efficacy of tecovirimat, a new antiviral agent, is shown in monkey and rabbit models, with supporting human pharmacokinetic data.

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Bibliographische Detailangaben
Veröffentlicht in:	The New England journal of medicine 2018-07, Vol.379 (1), p.44-53
Hauptverfasser:	Grosenbach, Douglas W, Honeychurch, Kady, Rose, Eric A, Chinsangaram, Jarasvech, Frimm, Annie, Maiti, Biswajit, Lovejoy, Candace, Meara, Ingrid, Long, Paul, Hruby, Dennis E
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral Adolescent Adult Aged Animal models Animals Antiviral Agents - administration & dosage Antiviral Agents - adverse effects Antiviral Agents - pharmacokinetics Benzamides - administration & dosage Benzamides - adverse effects Benzamides - pharmacokinetics Body weight Botulism Clinical trials Disease Disease Models, Animal Dose-Response Relationship, Drug Double-Blind Method Drug dosages FDA approval Female Fever Healthy Volunteers Humans Isoindoles - administration & dosage Isoindoles - adverse effects Isoindoles - pharmacokinetics Macaca fascicularis Male Middle Aged Monkeypox Monkeypox virus Monkeys & apes Mpox (monkeypox) - drug therapy Mpox (monkeypox) - mortality Poxviridae Infections - drug therapy Poxviridae Infections - mortality Primates Product development Rabbits Safety Smallpox Vaccinia virus Variola major Viruses Young Adult
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Beschreibung
Zusammenfassung:	There are no FDA-approved antiviral agents to treat infection with variola virus, the cause of smallpox. In this report, the efficacy of tecovirimat, a new antiviral agent, is shown in monkey and rabbit models, with supporting human pharmacokinetic data.
ISSN:	0028-4793 1533-4406
DOI:	10.1056/NEJMoa1705688