Induction and Amelioration of Methotrexate-Induced Gastrointestinal Toxicity are Related to Immune Response and Gut Microbiota

Induction and Amelioration of Methotrexate-Induced Gastrointestinal Toxicity are Related to Immune Response and Gut Microbiota

As a widely used anticancer and immunosuppressive agent, methotrexate (MTX) can induce multiple adverse drug reactions (ADRs), such as gastrointestinal toxicity, the mechanisms are poorly understood. Gut microbiota has been widely reported to be associated with the onset of multiple diseases as well...

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Veröffentlicht in:EBioMedicine 2018-07, Vol.33, p.122-133
Hauptverfasser: Zhou, Bailing, Xia, Xuyang, Wang, Peiqi, Chen, Shuang, Yu, Chaoheng, Huang, Rong, Zhang, Rui, Wang, Yantai, Lu, Lian, Yuan, Fengjiao, Tian, Yaomei, Fan, Yingzi, Zhang, Xueyan, Shu, Yang, Zhang, Shouyue, Bai, Ding, Wu, Lei, Xu, Heng, Yang, Li
Format: Artikel
Sprache:eng
Schlagworte:
Gastrointestinal toxicity
Gut microbiota
Methotrexate
Mononuclear phagocyte
Research Paper
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Zusammenfassung:As a widely used anticancer and immunosuppressive agent, methotrexate (MTX) can induce multiple adverse drug reactions (ADRs), such as gastrointestinal toxicity, the mechanisms are poorly understood. Gut microbiota has been widely reported to be associated with the onset of multiple diseases as well as treatment outcomes of different drugs. In this study, mucosal injury was observed in MTX-treated mice, leading to significant changes in macrophages (i.e., M1/M2 ratio, P 
ISSN:2352-3964
2352-3964
DOI:10.1016/j.ebiom.2018.06.029