Ca2+tapulting HSCs into action

Ca2+tapulting HSCs into action

In this issue of JEM, Umemoto et al. (https://doi.org/10.1084/jem.20180421) demonstrate that calcium influx stimulates mitochondrial metabolism and initiates proliferation in hematopoietic stem cells (HSCs). Extracellular adenosine, sourced from surrounding hematopoietic progenitors, inhibits this c...

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Veröffentlicht in:The Journal of experimental medicine 2018-08, Vol.215 (8), p.1971-1973
Hauptverfasser: Guitart, Amelie V., Finch, Andrew J., Kranc, Kamil R.
Format: Artikel
Sprache:eng
Schlagworte:
Adenosine
Calcium
Calcium (mitochondrial)
Calcium influx
Calcium metabolism
Cell proliferation
Hematology
Hematopoietic stem cells
Human health and pathology
Life Sciences
Metabolism
Mitochondria
Stem cells
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Zusammenfassung:In this issue of JEM, Umemoto et al. (https://doi.org/10.1084/jem.20180421) demonstrate that calcium influx stimulates mitochondrial metabolism and initiates proliferation in hematopoietic stem cells (HSCs). Extracellular adenosine, sourced from surrounding hematopoietic progenitors, inhibits this calcium influx, thereby suppressing mitochondrial metabolism and promoting HSC quiescence. This is the first demonstration that a calcium–mitochondria pathway regulates HSC division.
ISSN:0022-1007
1540-9538
DOI:10.1084/jem.20181097