Noninvasive Monitoring of Liver Disease Regression after Hepatitis C Eradication Using Gadoxetic Acid-Enhanced MRI

We evaluated changes in relative liver enhancement (RLE) obtained by gadoxetic acid-enhanced MRI (GA-MRI) in the hepatobiliary phase and changes in splenic volume (SV) after hepatitis C virus (HCV) eradication as well as their predictive value for the development of (further) hepatic decompensation...

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Veröffentlicht in:	Contrast media and molecular imaging 2018-01, Vol.2018 (2018), p.1-9
Hauptverfasser:	Peck-Radosavljevic, Markus, Ba-Ssalamah, Ahmed, Herold, Christian, Chromy, David, Hodge, Jacqueline C., Bastati, Nina, Reiberger, Thomas, Güngören, Zeynep, Mandorfer, Mattias, Haider, Lukas, Trauner, Michael
Format:	Artikel
Sprache:	eng
Schlagworte:	Acids Aged Bile Clinical Study Collateral Circulation Female Gadolinium DTPA - chemistry Gastroenterology Hepatitis Hepatitis C Hepatitis C - diagnosis Hepatitis C - pathology Hepatology Humans Hypertension Image Enhancement Inflammation Interferon Interferons - therapeutic use Liver Liver - pathology Liver cancer Liver diseases Magnetic Resonance Imaging Male Medical imaging Middle Aged NMR Nuclear magnetic resonance Patients Phase transitions Spleen Spleen - pathology Surveillance Transplants & implants Viruses
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Zusammenfassung:	We evaluated changes in relative liver enhancement (RLE) obtained by gadoxetic acid-enhanced MRI (GA-MRI) in the hepatobiliary phase and changes in splenic volume (SV) after hepatitis C virus (HCV) eradication as well as their predictive value for the development of (further) hepatic decompensation during follow-up. This retrospective study comprised 31 consecutive patients with HCV-induced advanced chronic liver disease who underwent GA-MRI before and after successful interferon-free treatment, as well as a cohort of 14 untreated chronic HCV-patients with paired GA-MRI. RLE increased by 66% (20%–94%; P
ISSN:	1555-4309 1555-4317
DOI:	10.1155/2018/8489709