The Association of Obesity and Cardiometabolic Traits With Incident HFpEF and HFrEF

The Association of Obesity and Cardiometabolic Traits With Incident HFpEF and HFrEF

This study evaluated the associations of obesity and cardiometabolic traits with incident heart failure with preserved versus reduced ejection fraction (HFpEF vs. HFrEF). Given known sex differences in HF subtype, we examined men and women separately. Recent studies suggest that obesity confers grea...

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Veröffentlicht in:JACC. Heart failure 2018-08, Vol.6 (8), p.701-709
Hauptverfasser: Savji, Nazir, Meijers, Wouter C., Bartz, Traci M., Bhambhani, Vijeta, Cushman, Mary, Nayor, Matthew, Kizer, Jorge R., Sarma, Amy, Blaha, Michael J., Gansevoort, Ron T., Gardin, Julius M., Hillege, Hans L., Ji, Fei, Kop, Willem J., Lau, Emily S., Lee, Douglas S., Sadreyev, Ruslan, van Gilst, Wiek H., Wang, Thomas J., Zanni, Markella V., Vasan, Ramachandran S., Allen, Norrina B., Psaty, Bruce M., van der Harst, Pim, Levy, Daniel, Larson, Martin, Shah, Sanjiv J., de Boer, Rudolf A., Gottdiener, John S., Ho, Jennifer E.
Format: Artikel
Sprache:eng
Schlagworte:
Adult
Aged
Blood Glucose - metabolism
Body Mass Index
Cholesterol - blood
Cholesterol, HDL - blood
Female
heart failure
Heart Failure - epidemiology
Heart Failure - physiopathology
HFpEF
Humans
Incidence
Insulin Resistance
Male
Metabolic Syndrome - epidemiology
Middle Aged
obesity
Obesity - epidemiology
Proportional Hazards Models
sex differences
Sex Factors
Stroke Volume
Triglycerides - blood
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Beschreibung
Zusammenfassung:This study evaluated the associations of obesity and cardiometabolic traits with incident heart failure with preserved versus reduced ejection fraction (HFpEF vs. HFrEF). Given known sex differences in HF subtype, we examined men and women separately. Recent studies suggest that obesity confers greater risk of HFpEF versus HFrEF. Contributions of associated metabolic traits to HFpEF are less clear. We studied 22,681 participants from 4 community-based cohorts followed for incident HFpEF versus HFrEF (ejection fraction ≥50% vs. 
ISSN:2213-1779
2213-1787
2213-1787
DOI:10.1016/j.jchf.2018.05.018