Cancer nanomedicine: from PDGF targeted drug delivery† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c7md00391a

An innovative approach for the distinctively efficient action of smart targeted drug delivery to a specific cell type is obtained through the modification of the surface of nanoparticles. An innovative approach for the distinctively efficient action of smart targeted drug delivery to a specific cell type is obtained through the modification of the surface of nanoparticles. Specifically, the work identifies a cell surface receptor targeting drug delivery nanosystem based on mesoporous silica loaded with the anticancer drug cisplatin ( cis -DDP) and poly-acrylic acid (PAA). A specific target is the PDGF receptors expressed in cervical cancer cells, thus making the PAA functionalized nanocomposite a suitable and promising nano-medicine for the targeting of PDGF-overexpressing cancers in the near future.