Longitudinal effects of aging on 18F-FDG distribution in cognitively normal elderly individuals

Previous studies of aging effects on fluorine-18-labeled fluorodeoxyglucose ( 18 F-FDG) distribution have employed cross-sectional designs. We examined aging effects on 18 F-FDG distribution using both cross-sectional and longitudinal assessments. We obtained two 18 F-FDG positron emission tomograph...

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Veröffentlicht in:	Scientific reports 2018-08, Vol.8 (1), p.1-8, Article 11557
Hauptverfasser:	Ishibashi, Kenji, Onishi, Airin, Fujiwara, Yoshinori, Oda, Keiichi, Ishiwata, Kiichi, Ishii, Kenji
Format:	Artikel
Sprache:	eng
Schlagworte:	59/78 631/378/2612 692/617 Aging Cortex (cingulate) Cortex (parietal) Geriatrics Humanities and Social Sciences multidisciplinary Older people Positron emission tomography Science Science (multidisciplinary)
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Zusammenfassung:	Previous studies of aging effects on fluorine-18-labeled fluorodeoxyglucose ( 18 F-FDG) distribution have employed cross-sectional designs. We examined aging effects on 18 F-FDG distribution using both cross-sectional and longitudinal assessments. We obtained two 18 F-FDG positron emission tomography scans at two different time points from 107 cognitively normal elderly participants. The participants’ mean ages at baseline and second scans were 67.9 and 75.7, respectively. The follow-up period ranged from 4 to 11 years with a mean of 7.8 years. The voxel-wise analysis revealed significant clusters in which 18 F-FDG uptake was decreased between baseline and second scans ( p
ISSN:	2045-2322 2045-2322
DOI:	10.1038/s41598-018-29937-y