Shaping neurodevelopment: distinct contributions of cytoskeletal proteins

Development of a neuron critically depends on the organization of its cytoskeleton. Cytoskeletal components, such as tubulins and actins, have the remarkable ability to organize themselves into filaments and networks to support specialized and compartmentalized functions. Alterations in cytoskeletal...

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Veröffentlicht in:Current opinion in neurobiology 2018-08, Vol.51, p.111-118
Hauptverfasser: Tang, Ngang Heok, Jin, Yishi
Format: Artikel
Sprache:eng
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Zusammenfassung:Development of a neuron critically depends on the organization of its cytoskeleton. Cytoskeletal components, such as tubulins and actins, have the remarkable ability to organize themselves into filaments and networks to support specialized and compartmentalized functions. Alterations in cytoskeletal proteins have long been associated with a variety of neurodevelopmental disorders. This review focuses on recent findings, primarily from forward genetic screens in Caenorhabditis elegans that illustrate how different tubulin protein isotypes can play distinct roles in neuronal development and function. Additionally, we discuss studies revealing new regulators of the actin cytoskeleton, and highlight recent technological advances in in vivo imaging and functional dissection of the neuronal cytoskeleton.
ISSN:0959-4388
1873-6882
1873-6882
DOI:10.1016/j.conb.2018.02.022