Hormetic dose response to L-ascorbic acid as an anti-cancer drug in colorectal cancer cell lines according to SVCT-2 expression

L -Ascorbic acid (vitamin C, AA) exhibits anti-cancer effects with high-dose treatment through the generation of reactive oxygen species (ROS) and selective damage to cancer cells. The anti-cancer effects of L -ascorbic acid are determined by sodium-dependent vitamin C transporter 2 (SVCT-2), a tran...

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Veröffentlicht in:	Scientific reports 2018-07, Vol.8 (1), p.11372-9, Article 11372
Hauptverfasser:	Cho, Sungrae, Chae, Jin Sung, Shin, Hocheol, Shin, Yujeong, Song, Haeun, Kim, Youngwook, Yoo, Byong Chul, Roh, Kangsan, Cho, Seungchan, Kil, Eui-joon, Byun, Hee-seong, Cho, Sang-ho, Park, Seyeon, Lee, Sukchan, Yeom, Chang-Hwan
Format:	Artikel
Sprache:	eng
Schlagworte:	13/31 14/34 38/77 631/67/1059 631/67/1059/602 82/1 82/51 Acids Ascorbic acid Cell proliferation Colorectal cancer Colorectal carcinoma Humanities and Social Sciences multidisciplinary Reactive oxygen species Science Science (multidisciplinary) Sodium Tumor cell lines Vitamin C
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Zusammenfassung:	L -Ascorbic acid (vitamin C, AA) exhibits anti-cancer effects with high-dose treatment through the generation of reactive oxygen species (ROS) and selective damage to cancer cells. The anti-cancer effects of L -ascorbic acid are determined by sodium-dependent vitamin C transporter 2 (SVCT-2), a transporter of L -ascorbic acid. In this study, we demonstrate that L -ascorbic acid treatment showed efficient anti-cancer activity in cell lines with high expression levels of SVCT-2 for a gradient concentration of L -ascorbic acid from 10 μM −2 mM. However, in low SVCT-2 expressing cell lines, high-dose L -ascorbic acid (>1 mM) showed anti-cancer effects but low-dose (
ISSN:	2045-2322 2045-2322
DOI:	10.1038/s41598-018-29386-7