The Human Cell Atlas: Technical approaches and challenges

The Human Cell Atlas: Technical approaches and challenges

Abstract The Human Cell Atlas is a large, international consortium that aims to identify and describe every cell type in the human body. The comprehensive cellular maps that arise from this ambitious effort have the potential to transform many aspects of fundamental biology and clinical practice. He...

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Veröffentlicht in:Briefings in functional genomics 2018-07, Vol.17 (4), p.283-294
Hauptverfasser: Hon, Chung-Chau, Shin, Jay W, Carninci, Piero, Stubbington, Michael J T
Format: Artikel
Sprache:eng
Schlagworte:
cell biology
Databases, Factual
Gene Expression Profiling
human health
human physiology
Humans
methodology
Sequence Analysis, RNA
Single-Cell Analysis
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Zusammenfassung:Abstract The Human Cell Atlas is a large, international consortium that aims to identify and describe every cell type in the human body. The comprehensive cellular maps that arise from this ambitious effort have the potential to transform many aspects of fundamental biology and clinical practice. Here, we discuss the technical approaches that could be used today to generate such a resource and also the technical challenges that will be encountered.
ISSN:2041-2649
2041-2657
2041-2657
DOI:10.1093/bfgp/elx029