The innate immune response to RSV: Advances in our understanding of critical viral and host factors

Highlights • Innate RSV control involves the coordinated action of various cellular processes. • These processes include cell stress, death, and innate immune responses. • RSV utilizes multiple mechanisms to evade the host responses. • RSV DVGs are the primary triggers of innate immunity in mice and humans. • New evidence suggests a critical role of DVGs in RSV pathogenesis.