Clinical Significance of the Decreased Expression of hsa_circ_001242 in Oral Squamous Cell Carcinoma
Background. Circular RNAs (circRNAs) are a type of covalently closed loop structure of endogenous RNAs. Recent studies have shown that circular RNAs may play an important role in human cancer. However, there is limited information on the function of circRNA in oral squamous cell carcinoma (OSCC). Me...
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description | Background. Circular RNAs (circRNAs) are a type of covalently closed loop structure of endogenous RNAs. Recent studies have shown that circular RNAs may play an important role in human cancer. However, there is limited information on the function of circRNA in oral squamous cell carcinoma (OSCC). Methods. Hsa_circ_001242 expression levels in 40 paired OSCC tissues and four OSCC cell lines were selected using real-time quantitative reverse transcription polymerase chain reaction (qRT-PCR). A receiver operating characteristic (ROC) curve was used to evaluate the diagnostic value of hsa_circ_001242 in OSCC. Results. Hsa_circ_001242 was significantly downregulated in OSCC tissues compared to paired adjacent normal tissues (P |
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Circular RNAs (circRNAs) are a type of covalently closed loop structure of endogenous RNAs. Recent studies have shown that circular RNAs may play an important role in human cancer. However, there is limited information on the function of circRNA in oral squamous cell carcinoma (OSCC). Methods. Hsa_circ_001242 expression levels in 40 paired OSCC tissues and four OSCC cell lines were selected using real-time quantitative reverse transcription polymerase chain reaction (qRT-PCR). A receiver operating characteristic (ROC) curve was used to evaluate the diagnostic value of hsa_circ_001242 in OSCC. Results. Hsa_circ_001242 was significantly downregulated in OSCC tissues compared to paired adjacent normal tissues (P<0.001). Hsa_circ_001242 expression levels were significantly downregulated in four OSCC cell lines (SCC-9, SCC-15, SCC25, and CAL-27) than in human normal oral keratinocyte (HOK) cell lines. Moreover, the expression level of hsa_circ_001242 was negatively correlated with tumor size and T stage (P<0.05). The area under the ROC curve was 0.784. Conclusion. This study showed that hsa_circ_001242 was significantly downregulated in OSCC and may act as a potential novel biomarker for the diagnosis and treatment of OSCC.</description><identifier>ISSN: 0278-0240</identifier><identifier>EISSN: 1875-8630</identifier><identifier>DOI: 10.1155/2018/6514795</identifier><identifier>PMID: 30069275</identifier><language>eng</language><publisher>Cairo, Egypt: Hindawi Publishing Corporation</publisher><subject>Biomarkers ; Biomarkers, Tumor - genetics ; Biomarkers, Tumor - metabolism ; Biotechnology ; Cancer therapies ; Carcinoma, Squamous Cell - genetics ; Carcinoma, Squamous Cell - metabolism ; Carcinoma, Squamous Cell - pathology ; Cell growth ; Cell Line, Tumor ; Clinical significance ; Diagnosis ; Diagnostic systems ; Down-Regulation ; Female ; Health savings accounts ; Humans ; Keratinocytes - metabolism ; Male ; Medical research ; Middle Aged ; Mouth Neoplasms - genetics ; Mouth Neoplasms - metabolism ; Mouth Neoplasms - pathology ; Oral squamous cell carcinoma ; Penicillin ; Polymerase chain reaction ; Reverse transcription ; RNA - genetics ; RNA - metabolism ; RNA, Circular ; Software ; Squamous cell carcinoma ; Tissues</subject><ispartof>Disease markers, 2018-01, Vol.2018 (2018), p.1-6</ispartof><rights>Copyright © 2018 Shuai Sun et al.</rights><rights>COPYRIGHT 2018 John Wiley & Sons, Inc.</rights><rights>Copyright © 2018 Shuai Sun et al. This is an open access article distributed under the Creative Commons Attribution License (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. http://creativecommons.org/licenses/by/4.0</rights><rights>Copyright © 2018 Shuai Sun et al. 2018</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c499t-6e3acece18ad7fbc4c35a4bcb2880f4f36a261c0d0c2eaec787085c5ad55bdeb3</citedby><cites>FETCH-LOGICAL-c499t-6e3acece18ad7fbc4c35a4bcb2880f4f36a261c0d0c2eaec787085c5ad55bdeb3</cites><orcidid>0000-0002-0367-4938 ; 0000-0003-2255-5405</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6057325/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6057325/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30069275$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Yee, Nelson</contributor><creatorcontrib>Yang, Hongyu</creatorcontrib><creatorcontrib>Wang, Feng</creatorcontrib><creatorcontrib>Wang, Panpan</creatorcontrib><creatorcontrib>Li, Xiang</creatorcontrib><creatorcontrib>Wang, Yu-Fan</creatorcontrib><creatorcontrib>Li, Bowen</creatorcontrib><creatorcontrib>Sun, Shuai</creatorcontrib><creatorcontrib>Zhang, Wei</creatorcontrib><title>Clinical Significance of the Decreased Expression of hsa_circ_001242 in Oral Squamous Cell Carcinoma</title><title>Disease markers</title><addtitle>Dis Markers</addtitle><description>Background. Circular RNAs (circRNAs) are a type of covalently closed loop structure of endogenous RNAs. Recent studies have shown that circular RNAs may play an important role in human cancer. However, there is limited information on the function of circRNA in oral squamous cell carcinoma (OSCC). Methods. Hsa_circ_001242 expression levels in 40 paired OSCC tissues and four OSCC cell lines were selected using real-time quantitative reverse transcription polymerase chain reaction (qRT-PCR). A receiver operating characteristic (ROC) curve was used to evaluate the diagnostic value of hsa_circ_001242 in OSCC. Results. Hsa_circ_001242 was significantly downregulated in OSCC tissues compared to paired adjacent normal tissues (P<0.001). Hsa_circ_001242 expression levels were significantly downregulated in four OSCC cell lines (SCC-9, SCC-15, SCC25, and CAL-27) than in human normal oral keratinocyte (HOK) cell lines. Moreover, the expression level of hsa_circ_001242 was negatively correlated with tumor size and T stage (P<0.05). The area under the ROC curve was 0.784. Conclusion. This study showed that hsa_circ_001242 was significantly downregulated in OSCC and may act as a potential novel biomarker for the diagnosis and treatment of OSCC.</description><subject>Biomarkers</subject><subject>Biomarkers, Tumor - genetics</subject><subject>Biomarkers, Tumor - metabolism</subject><subject>Biotechnology</subject><subject>Cancer therapies</subject><subject>Carcinoma, Squamous Cell - genetics</subject><subject>Carcinoma, Squamous Cell - metabolism</subject><subject>Carcinoma, Squamous Cell - pathology</subject><subject>Cell growth</subject><subject>Cell Line, Tumor</subject><subject>Clinical significance</subject><subject>Diagnosis</subject><subject>Diagnostic systems</subject><subject>Down-Regulation</subject><subject>Female</subject><subject>Health savings accounts</subject><subject>Humans</subject><subject>Keratinocytes - metabolism</subject><subject>Male</subject><subject>Medical research</subject><subject>Middle Aged</subject><subject>Mouth Neoplasms - genetics</subject><subject>Mouth Neoplasms - metabolism</subject><subject>Mouth Neoplasms - pathology</subject><subject>Oral squamous cell carcinoma</subject><subject>Penicillin</subject><subject>Polymerase chain reaction</subject><subject>Reverse transcription</subject><subject>RNA - genetics</subject><subject>RNA - metabolism</subject><subject>RNA, Circular</subject><subject>Software</subject><subject>Squamous cell carcinoma</subject><subject>Tissues</subject><issn>0278-0240</issn><issn>1875-8630</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>RHX</sourceid><sourceid>EIF</sourceid><recordid>eNqNkc9rFDEYhoNY7Fq9eZYBL0Idm2Qmk-RSKNOqhUIP6jlkvvlmN2Um2SY7_vjvzbBrq56EQALfw5Pv5SXkFaPvGRPijFOmzhrBaqnFE7JiSopSNRV9SlaUS1VSXtNj8jylO0oZ17V-Ro4rShvNpViRvh2dd2DH4rNbezfkpwcswlDsNlhcIkS0Cfvi6sc2Ykou-GW2SdaAi2AWZc0L54vbuDjuZzuFORUtjmPR2gjOh8m-IEeDHRO-PNwn5OuHqy_tp_Lm9uN1e3FTQq31rmywsoCATNleDh3UUAlbd9BxpehQD1VjecOA9hQ4WgSpJFUChO2F6HrsqhNyvvdu527CHtDv8lZmG91k408TrDN_T7zbmHX4ZhoqZMVFFrw9CGK4nzHtzOQS5CzWY45lOFX5aE0X9M0_6F2Yo8_xMiUpY4pJ_Uit7YjG-SHkf2GRmguhZCOE0ixT7_YUxJBSxOFhZUbNUrJZSjaHkjP--s-YD_DvVjNwugc2zvf2u_tPHWYGB_tIM1EJLqtfwVq4Ww</recordid><startdate>20180101</startdate><enddate>20180101</enddate><creator>Yang, Hongyu</creator><creator>Wang, Feng</creator><creator>Wang, Panpan</creator><creator>Li, Xiang</creator><creator>Wang, Yu-Fan</creator><creator>Li, Bowen</creator><creator>Sun, Shuai</creator><creator>Zhang, Wei</creator><general>Hindawi Publishing Corporation</general><general>Hindawi</general><general>John Wiley & Sons, Inc</general><general>Hindawi Limited</general><scope>ADJCN</scope><scope>AHFXO</scope><scope>RHU</scope><scope>RHW</scope><scope>RHX</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7QO</scope><scope>7TK</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-0367-4938</orcidid><orcidid>https://orcid.org/0000-0003-2255-5405</orcidid></search><sort><creationdate>20180101</creationdate><title>Clinical Significance of the Decreased Expression of hsa_circ_001242 in Oral Squamous Cell Carcinoma</title><author>Yang, Hongyu ; Wang, Feng ; Wang, Panpan ; Li, Xiang ; Wang, Yu-Fan ; Li, Bowen ; Sun, Shuai ; Zhang, Wei</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c499t-6e3acece18ad7fbc4c35a4bcb2880f4f36a261c0d0c2eaec787085c5ad55bdeb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Biomarkers</topic><topic>Biomarkers, Tumor - genetics</topic><topic>Biomarkers, Tumor - metabolism</topic><topic>Biotechnology</topic><topic>Cancer therapies</topic><topic>Carcinoma, Squamous Cell - genetics</topic><topic>Carcinoma, Squamous Cell - metabolism</topic><topic>Carcinoma, Squamous Cell - pathology</topic><topic>Cell growth</topic><topic>Cell Line, Tumor</topic><topic>Clinical significance</topic><topic>Diagnosis</topic><topic>Diagnostic systems</topic><topic>Down-Regulation</topic><topic>Female</topic><topic>Health savings accounts</topic><topic>Humans</topic><topic>Keratinocytes - metabolism</topic><topic>Male</topic><topic>Medical research</topic><topic>Middle Aged</topic><topic>Mouth Neoplasms - genetics</topic><topic>Mouth Neoplasms - metabolism</topic><topic>Mouth Neoplasms - pathology</topic><topic>Oral squamous cell carcinoma</topic><topic>Penicillin</topic><topic>Polymerase chain reaction</topic><topic>Reverse transcription</topic><topic>RNA - genetics</topic><topic>RNA - metabolism</topic><topic>RNA, Circular</topic><topic>Software</topic><topic>Squamous cell carcinoma</topic><topic>Tissues</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yang, Hongyu</creatorcontrib><creatorcontrib>Wang, Feng</creatorcontrib><creatorcontrib>Wang, Panpan</creatorcontrib><creatorcontrib>Li, Xiang</creatorcontrib><creatorcontrib>Wang, Yu-Fan</creatorcontrib><creatorcontrib>Li, Bowen</creatorcontrib><creatorcontrib>Sun, Shuai</creatorcontrib><creatorcontrib>Zhang, Wei</creatorcontrib><collection>الدوريات العلمية والإحصائية - e-Marefa Academic and Statistical Periodicals</collection><collection>معرفة - المحتوى العربي الأكاديمي المتكامل - e-Marefa Academic Complete</collection><collection>Hindawi Publishing Complete</collection><collection>Hindawi Publishing Subscription Journals</collection><collection>Hindawi Publishing Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Disease markers</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yang, Hongyu</au><au>Wang, Feng</au><au>Wang, Panpan</au><au>Li, Xiang</au><au>Wang, Yu-Fan</au><au>Li, Bowen</au><au>Sun, Shuai</au><au>Zhang, Wei</au><au>Yee, Nelson</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Clinical Significance of the Decreased Expression of hsa_circ_001242 in Oral Squamous Cell Carcinoma</atitle><jtitle>Disease markers</jtitle><addtitle>Dis Markers</addtitle><date>2018-01-01</date><risdate>2018</risdate><volume>2018</volume><issue>2018</issue><spage>1</spage><epage>6</epage><pages>1-6</pages><issn>0278-0240</issn><eissn>1875-8630</eissn><abstract>Background. Circular RNAs (circRNAs) are a type of covalently closed loop structure of endogenous RNAs. Recent studies have shown that circular RNAs may play an important role in human cancer. However, there is limited information on the function of circRNA in oral squamous cell carcinoma (OSCC). Methods. Hsa_circ_001242 expression levels in 40 paired OSCC tissues and four OSCC cell lines were selected using real-time quantitative reverse transcription polymerase chain reaction (qRT-PCR). A receiver operating characteristic (ROC) curve was used to evaluate the diagnostic value of hsa_circ_001242 in OSCC. Results. Hsa_circ_001242 was significantly downregulated in OSCC tissues compared to paired adjacent normal tissues (P<0.001). Hsa_circ_001242 expression levels were significantly downregulated in four OSCC cell lines (SCC-9, SCC-15, SCC25, and CAL-27) than in human normal oral keratinocyte (HOK) cell lines. Moreover, the expression level of hsa_circ_001242 was negatively correlated with tumor size and T stage (P<0.05). The area under the ROC curve was 0.784. Conclusion. This study showed that hsa_circ_001242 was significantly downregulated in OSCC and may act as a potential novel biomarker for the diagnosis and treatment of OSCC.</abstract><cop>Cairo, Egypt</cop><pub>Hindawi Publishing Corporation</pub><pmid>30069275</pmid><doi>10.1155/2018/6514795</doi><tpages>6</tpages><orcidid>https://orcid.org/0000-0002-0367-4938</orcidid><orcidid>https://orcid.org/0000-0003-2255-5405</orcidid><oa>free_for_read</oa></addata></record> |
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subjects | Biomarkers Biomarkers, Tumor - genetics Biomarkers, Tumor - metabolism Biotechnology Cancer therapies Carcinoma, Squamous Cell - genetics Carcinoma, Squamous Cell - metabolism Carcinoma, Squamous Cell - pathology Cell growth Cell Line, Tumor Clinical significance Diagnosis Diagnostic systems Down-Regulation Female Health savings accounts Humans Keratinocytes - metabolism Male Medical research Middle Aged Mouth Neoplasms - genetics Mouth Neoplasms - metabolism Mouth Neoplasms - pathology Oral squamous cell carcinoma Penicillin Polymerase chain reaction Reverse transcription RNA - genetics RNA - metabolism RNA, Circular Software Squamous cell carcinoma Tissues |
title | Clinical Significance of the Decreased Expression of hsa_circ_001242 in Oral Squamous Cell Carcinoma |
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