Clinical Significance of the Decreased Expression of hsa_circ_001242 in Oral Squamous Cell Carcinoma

Background. Circular RNAs (circRNAs) are a type of covalently closed loop structure of endogenous RNAs. Recent studies have shown that circular RNAs may play an important role in human cancer. However, there is limited information on the function of circRNA in oral squamous cell carcinoma (OSCC). Me...

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Veröffentlicht in:Disease markers 2018-01, Vol.2018 (2018), p.1-6
Hauptverfasser: Yang, Hongyu, Wang, Feng, Wang, Panpan, Li, Xiang, Wang, Yu-Fan, Li, Bowen, Sun, Shuai, Zhang, Wei
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container_end_page 6
container_issue 2018
container_start_page 1
container_title Disease markers
container_volume 2018
creator Yang, Hongyu
Wang, Feng
Wang, Panpan
Li, Xiang
Wang, Yu-Fan
Li, Bowen
Sun, Shuai
Zhang, Wei
description Background. Circular RNAs (circRNAs) are a type of covalently closed loop structure of endogenous RNAs. Recent studies have shown that circular RNAs may play an important role in human cancer. However, there is limited information on the function of circRNA in oral squamous cell carcinoma (OSCC). Methods. Hsa_circ_001242 expression levels in 40 paired OSCC tissues and four OSCC cell lines were selected using real-time quantitative reverse transcription polymerase chain reaction (qRT-PCR). A receiver operating characteristic (ROC) curve was used to evaluate the diagnostic value of hsa_circ_001242 in OSCC. Results. Hsa_circ_001242 was significantly downregulated in OSCC tissues compared to paired adjacent normal tissues (P
doi_str_mv 10.1155/2018/6514795
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Circular RNAs (circRNAs) are a type of covalently closed loop structure of endogenous RNAs. Recent studies have shown that circular RNAs may play an important role in human cancer. However, there is limited information on the function of circRNA in oral squamous cell carcinoma (OSCC). Methods. Hsa_circ_001242 expression levels in 40 paired OSCC tissues and four OSCC cell lines were selected using real-time quantitative reverse transcription polymerase chain reaction (qRT-PCR). A receiver operating characteristic (ROC) curve was used to evaluate the diagnostic value of hsa_circ_001242 in OSCC. Results. Hsa_circ_001242 was significantly downregulated in OSCC tissues compared to paired adjacent normal tissues (P&lt;0.001). Hsa_circ_001242 expression levels were significantly downregulated in four OSCC cell lines (SCC-9, SCC-15, SCC25, and CAL-27) than in human normal oral keratinocyte (HOK) cell lines. Moreover, the expression level of hsa_circ_001242 was negatively correlated with tumor size and T stage (P&lt;0.05). The area under the ROC curve was 0.784. Conclusion. This study showed that hsa_circ_001242 was significantly downregulated in OSCC and may act as a potential novel biomarker for the diagnosis and treatment of OSCC.</description><identifier>ISSN: 0278-0240</identifier><identifier>EISSN: 1875-8630</identifier><identifier>DOI: 10.1155/2018/6514795</identifier><identifier>PMID: 30069275</identifier><language>eng</language><publisher>Cairo, Egypt: Hindawi Publishing Corporation</publisher><subject>Biomarkers ; Biomarkers, Tumor - genetics ; Biomarkers, Tumor - metabolism ; Biotechnology ; Cancer therapies ; Carcinoma, Squamous Cell - genetics ; Carcinoma, Squamous Cell - metabolism ; Carcinoma, Squamous Cell - pathology ; Cell growth ; Cell Line, Tumor ; Clinical significance ; Diagnosis ; Diagnostic systems ; Down-Regulation ; Female ; Health savings accounts ; Humans ; Keratinocytes - metabolism ; Male ; Medical research ; Middle Aged ; Mouth Neoplasms - genetics ; Mouth Neoplasms - metabolism ; Mouth Neoplasms - pathology ; Oral squamous cell carcinoma ; Penicillin ; Polymerase chain reaction ; Reverse transcription ; RNA - genetics ; RNA - metabolism ; RNA, Circular ; Software ; Squamous cell carcinoma ; Tissues</subject><ispartof>Disease markers, 2018-01, Vol.2018 (2018), p.1-6</ispartof><rights>Copyright © 2018 Shuai Sun et al.</rights><rights>COPYRIGHT 2018 John Wiley &amp; Sons, Inc.</rights><rights>Copyright © 2018 Shuai Sun et al. This is an open access article distributed under the Creative Commons Attribution License (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. http://creativecommons.org/licenses/by/4.0</rights><rights>Copyright © 2018 Shuai Sun et al. 2018</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c499t-6e3acece18ad7fbc4c35a4bcb2880f4f36a261c0d0c2eaec787085c5ad55bdeb3</citedby><cites>FETCH-LOGICAL-c499t-6e3acece18ad7fbc4c35a4bcb2880f4f36a261c0d0c2eaec787085c5ad55bdeb3</cites><orcidid>0000-0002-0367-4938 ; 0000-0003-2255-5405</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6057325/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6057325/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30069275$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Yee, Nelson</contributor><creatorcontrib>Yang, Hongyu</creatorcontrib><creatorcontrib>Wang, Feng</creatorcontrib><creatorcontrib>Wang, Panpan</creatorcontrib><creatorcontrib>Li, Xiang</creatorcontrib><creatorcontrib>Wang, Yu-Fan</creatorcontrib><creatorcontrib>Li, Bowen</creatorcontrib><creatorcontrib>Sun, Shuai</creatorcontrib><creatorcontrib>Zhang, Wei</creatorcontrib><title>Clinical Significance of the Decreased Expression of hsa_circ_001242 in Oral Squamous Cell Carcinoma</title><title>Disease markers</title><addtitle>Dis Markers</addtitle><description>Background. Circular RNAs (circRNAs) are a type of covalently closed loop structure of endogenous RNAs. Recent studies have shown that circular RNAs may play an important role in human cancer. However, there is limited information on the function of circRNA in oral squamous cell carcinoma (OSCC). Methods. Hsa_circ_001242 expression levels in 40 paired OSCC tissues and four OSCC cell lines were selected using real-time quantitative reverse transcription polymerase chain reaction (qRT-PCR). A receiver operating characteristic (ROC) curve was used to evaluate the diagnostic value of hsa_circ_001242 in OSCC. Results. Hsa_circ_001242 was significantly downregulated in OSCC tissues compared to paired adjacent normal tissues (P&lt;0.001). Hsa_circ_001242 expression levels were significantly downregulated in four OSCC cell lines (SCC-9, SCC-15, SCC25, and CAL-27) than in human normal oral keratinocyte (HOK) cell lines. 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Circular RNAs (circRNAs) are a type of covalently closed loop structure of endogenous RNAs. Recent studies have shown that circular RNAs may play an important role in human cancer. However, there is limited information on the function of circRNA in oral squamous cell carcinoma (OSCC). Methods. Hsa_circ_001242 expression levels in 40 paired OSCC tissues and four OSCC cell lines were selected using real-time quantitative reverse transcription polymerase chain reaction (qRT-PCR). A receiver operating characteristic (ROC) curve was used to evaluate the diagnostic value of hsa_circ_001242 in OSCC. Results. Hsa_circ_001242 was significantly downregulated in OSCC tissues compared to paired adjacent normal tissues (P&lt;0.001). Hsa_circ_001242 expression levels were significantly downregulated in four OSCC cell lines (SCC-9, SCC-15, SCC25, and CAL-27) than in human normal oral keratinocyte (HOK) cell lines. Moreover, the expression level of hsa_circ_001242 was negatively correlated with tumor size and T stage (P&lt;0.05). The area under the ROC curve was 0.784. Conclusion. This study showed that hsa_circ_001242 was significantly downregulated in OSCC and may act as a potential novel biomarker for the diagnosis and treatment of OSCC.</abstract><cop>Cairo, Egypt</cop><pub>Hindawi Publishing Corporation</pub><pmid>30069275</pmid><doi>10.1155/2018/6514795</doi><tpages>6</tpages><orcidid>https://orcid.org/0000-0002-0367-4938</orcidid><orcidid>https://orcid.org/0000-0003-2255-5405</orcidid><oa>free_for_read</oa></addata></record>
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subjects Biomarkers
Biomarkers, Tumor - genetics
Biomarkers, Tumor - metabolism
Biotechnology
Cancer therapies
Carcinoma, Squamous Cell - genetics
Carcinoma, Squamous Cell - metabolism
Carcinoma, Squamous Cell - pathology
Cell growth
Cell Line, Tumor
Clinical significance
Diagnosis
Diagnostic systems
Down-Regulation
Female
Health savings accounts
Humans
Keratinocytes - metabolism
Male
Medical research
Middle Aged
Mouth Neoplasms - genetics
Mouth Neoplasms - metabolism
Mouth Neoplasms - pathology
Oral squamous cell carcinoma
Penicillin
Polymerase chain reaction
Reverse transcription
RNA - genetics
RNA - metabolism
RNA, Circular
Software
Squamous cell carcinoma
Tissues
title Clinical Significance of the Decreased Expression of hsa_circ_001242 in Oral Squamous Cell Carcinoma
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