Is Total Serum Nitrite and Nitrate (NOx) Level in Dengue Patients a Potential Prognostic Marker of Dengue Hemorrhagic Fever?

Is Total Serum Nitrite and Nitrate (NOx) Level in Dengue Patients a Potential Prognostic Marker of Dengue Hemorrhagic Fever?

Potential use of total nitrite plus nitrate (NOx) and nitrite (NO2−) separately as surrogate markers for serum nitric oxide in severe dengue and their longitudinal changes along with the progression of infection was studied. Deproteinized sera from confirmed dengue fever (DF, n=145) and dengue hemor...

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Veröffentlicht in:Disease markers 2018-01, Vol.2018 (2018), p.1-9
Hauptverfasser: Premawansa, Sunil, De Silva, Aruna Dharshan, Kanapathippillai, Karunayokiny, Fernando, Tharanga, Thillainathan, Sharmila, Premawansa, I. H. G. S., Handunnetti, Shiroma, Mapalagamage, Maheshi, Wickremasinghe, Rajitha
Format: Artikel
Sprache:eng
Schlagworte:
Adolescent
Adult
Biomarkers - blood
Case-Control Studies
Comparative analysis
Convalescence
Dengue - blood
Dengue fever
Dengue hemorrhagic fever
Development and progression
Female
Fever
Flavivirus
Health aspects
Humans
Infection
Male
Medical research
Medicine, Experimental
Middle Aged
Nitrates
Nitrates - blood
Nitric oxide
Nitrites
Nitrites - blood
Nitrogen dioxide
Nitrogen oxides
Patients
Prognosis
Sensitivity
Sensitivity and Specificity
Vector-borne diseases
Viral diseases
Viral infections
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Zusammenfassung:Potential use of total nitrite plus nitrate (NOx) and nitrite (NO2−) separately as surrogate markers for serum nitric oxide in severe dengue and their longitudinal changes along with the progression of infection was studied. Deproteinized sera from confirmed dengue fever (DF, n=145) and dengue hemorrhagic fever (DHF, n=74) patients on admission—A, critical—C, discharge—D, and convalescence—CON stages and from age-gender matched healthy individuals (HC, n=77) were taken to assess NO2− and NOx levels using Griess and modified Griess assays. Serum NOx in DHFA was significantly lower compared to DFA (p
ISSN:0278-0240
1875-8630
DOI:10.1155/2018/5328681