Chemical Strategies for Half-Life Extension of Biopharmaceuticals: Lipidation and Its Alternatives
Strategies for half-life extension are often required in the design of new biopharmaceuticals. This Viewpoint focuses on chemical moieties that convey protraction by albumin binding or by self-assembly to form larger structures, with GLP-1 and insulin as examples.
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| Veröffentlicht in: | ACS medicinal chemistry letters 2018-07, Vol.9 (7), p.577-580 |
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| Hauptverfasser: | , , |
| Format: | Artikel |
| Sprache: | eng |
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| Online-Zugang: | Volltext |
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| Zusammenfassung: | Strategies for half-life extension are often required in the design of new biopharmaceuticals. This Viewpoint focuses on chemical moieties that convey protraction by albumin binding or by self-assembly to form larger structures, with GLP-1 and insulin as examples. |
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| ISSN: | 1948-5875 1948-5875 |
| DOI: | 10.1021/acsmedchemlett.8b00226 |