Lack of association between PER3 variable number tandem repeat and circadian rhythm sleep–wake disorders

Lack of association between PER3 variable number tandem repeat and circadian rhythm sleep–wake disorders

Circadian rhythm sleep–wake disorders (CRSWDs) are characterized by disturbed sleep–wake patterns. We genotyped a PER3 variable number tandem repeat (VNTR) in 248 CRSWD individuals and 925 controls and found no significant association between the VNTR and CRSWDs or morningness–eveningness (diurnal)...

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Veröffentlicht in:Human genome variation 2018-07, Vol.5 (1), p.17-4, Article 17
Hauptverfasser: Hida, Akiko, Kitamura, Shingo, Kadotani, Hiroshi, Uchiyama, Makoto, Ebisawa, Takashi, Inoue, Yuichi, Kamei, Yuichi, Mishima, Kazuo
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Sprache:eng
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631/208/1515
631/208/721
Biomedical and Life Sciences
Biomedicine
Circadian rhythm
Data Report
Gene Expression
Gene Function
Gene Therapy
Human Genetics
Molecular Medicine
Sleep
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Zusammenfassung:Circadian rhythm sleep–wake disorders (CRSWDs) are characterized by disturbed sleep–wake patterns. We genotyped a PER3 variable number tandem repeat (VNTR) in 248 CRSWD individuals and 925 controls and found no significant association between the VNTR and CRSWDs or morningness–eveningness (diurnal) preferences in the Japanese population. Although the VNTR has been associated with circadian and sleep phenotypes in some other populations, the polymorphism may not be a universal genetic marker.
ISSN:2054-345X
2054-345X
DOI:10.1038/s41439-018-0017-7