Differentiation of Normal and Radioresistant Prostate Cancer Xenografts Using Magnetization Transfer-Prepared MRI

Differentiation of Normal and Radioresistant Prostate Cancer Xenografts Using Magnetization Transfer-Prepared MRI

The ability of MRI to differentiate between normal and radioresistant cancer was investigated in prostate tumour xenografts in mice. Specifically, the process of magnetization exchange between water and other molecules was studied. It was found that magnetization transfer from semisolid macromolecul...

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Veröffentlicht in:Scientific reports 2018-07, Vol.8 (1), p.10447-10, Article 10447
Hauptverfasser: Lam, Wilfred W., Oakden, Wendy, Murray, Leedan, Klein, Jonathan, Iorio, Caterina, Screaton, Robert A., Koletar, Margaret M., Chu, William, Liu, Stanley K., Stanisz, Greg J.
Format: Artikel
Sprache:eng
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Humanities and Social Sciences
Macromolecules
Magnetic resonance imaging
Metabolic rate
Metabolism
multidisciplinary
Prostate
Prostate cancer
Radiosensitivity
Science
Science (multidisciplinary)
Tumors
Xenografts
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Zusammenfassung:The ability of MRI to differentiate between normal and radioresistant cancer was investigated in prostate tumour xenografts in mice. Specifically, the process of magnetization exchange between water and other molecules was studied. It was found that magnetization transfer from semisolid macromolecules (MT) and chemical exchange saturation transfer (CEST) combined were significantly different between groups ( p  
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-018-28731-0