Role of Cellular Metabolism in Pulmonary Diseases

Cell Metab (6) Reviewed by Parker S. Woods During lung infection, both resident and infiltrating immune cells encounter varying oxygen and nutrient conditions, which may negatively affect their effector function. [...]immune cells must compete with pathogens for nutrients, which are often limited locally at infection sites. [...]to overcome these metabolic stresses and to build an adequate effector response, immune cells need to have the flexibility to substantially alter their metabolic activity. Understanding the metabolic fate of nutrients in activated immune cells may enhance the ability to treat and/or prevent such conditions by targeting distinct metabolic pathways. [...]it may be necessary to consider the metabolic needs of cells within a distinct tissue location when treating a disease or infection. [...]the authors confirmed the importance of glutamate-NMDA receptor axis in two rodent models of pulmonary hypertension.