Tumor‐infiltrating neutrophils predict prognosis and adjuvant chemotherapeutic benefit in patients with biliary cancer

Tumor‐infiltrating neutrophils (TIN) carry out quite significant but opposite functions in different cancers, and their function in biliary cancer has not been fully characterized. To investigate the prognostic significance of TIN in biliary cancer, a training set (n = 118) and a validation set (n =...

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Veröffentlicht in:	Cancer science 2018-07, Vol.109 (7), p.2266-2274
Hauptverfasser:	Wang, Jie, Bo, Xiaobo, Suo, Tao, Liu, Han, Ni, Xiaoling, Shen, Sheng, Li, Min, Xu, Jiejie, Liu, Houbao, Wang, Yueqi
Format:	Artikel
Sprache:	eng
Schlagworte:	adjuvant chemotherapy Adult Aged Area Under Curve Bile Duct Neoplasms - mortality Bile Duct Neoplasms - pathology Bile Duct Neoplasms - therapy biliary cancer Cancer CD8 antigen Cell adhesion & migration Cell proliferation Chemotherapy Chemotherapy, Adjuvant Cholangiocarcinoma - mortality Cholangiocarcinoma - pathology Cholangiocarcinoma - therapy Female Gallbladder Gallbladder Neoplasms - mortality Gallbladder Neoplasms - pathology Gallbladder Neoplasms - therapy Gastric cancer Humans immunosuppression Inflammation Kaplan-Meier Estimate Leukocytes (neutrophilic) Lymphocytes T Male Medical prognosis Melanoma Middle Aged Neutropenia Neutrophils Neutrophils - pathology Original Patients Prognosis Proportional Hazards Models ROC Curve Roles Surgery tumor infiltrating neutrophil Tumor Microenvironment - immunology Tumors
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Zusammenfassung:	Tumor‐infiltrating neutrophils (TIN) carry out quite significant but opposite functions in different cancers, and their function in biliary cancer has not been fully characterized. To investigate the prognostic significance of TIN in biliary cancer, a training set (n = 118) and a validation set (n = 127) were involved in this study. TIN were evaluated by immunohistochemical staining of CD66b, and then defined as low (neutrophils
ISSN:	1347-9032 1349-7006
DOI:	10.1111/cas.13627