Regulating the regulator: Bhlhe40 directly keeps IL-10 in check

Regulating the regulator: Bhlhe40 directly keeps IL-10 in check

In this issue of , two complementary manuscripts by Huynh et al. (https://doi.org/10.1084/jem.20171704) and Yu et al. (https://doi.org/10.1084/jem.20170155) demonstrate that the transcription factor Bhlhe40 acts as a repressor of IL-10 production during infection with or Deletion of Bhlhe40 in both...

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Veröffentlicht in:The Journal of experimental medicine 2018-07, Vol.215 (7), p.1767-1769
Hauptverfasser: Gabryšová, Leona, O'Garra, Anne
Format: Artikel
Sprache:eng
Schlagworte:
Chronic infection
Humans
Infections
Interleukin 10
Mycobacterium tuberculosis
Pathogens
Toxoplasma gondii
Transcription factors
Tuberculosis
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Zusammenfassung:In this issue of , two complementary manuscripts by Huynh et al. (https://doi.org/10.1084/jem.20171704) and Yu et al. (https://doi.org/10.1084/jem.20170155) demonstrate that the transcription factor Bhlhe40 acts as a repressor of IL-10 production during infection with or Deletion of Bhlhe40 in both cases resulted in chronic infection and increased pathogen load as a consequence of increased IL-10 production.
ISSN:0022-1007
1540-9538
1540-9538
DOI:10.1084/jem.20180824